{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:24:52Z","timestamp":1777447492266,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Background<\/jats:title>Left ventricular (LV<\/jats:styled-content>) diastolic dysfunction depends on an impaired relaxation and stiffness. Abnormal LV<\/jats:styled-content> relaxation contributes to the development of atrial fibrillation (AF<\/jats:styled-content>), but the role of LV<\/jats:styled-content> stiffness in AF<\/jats:styled-content> remains unclear.<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>Diastolic wall strain (DWS<\/jats:styled-content>), a load\u2010independent, noninvasive direct measure of LV<\/jats:styled-content> stiffness, correlates with prevalent AF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>This study included 328 consecutive subjects with structurally normal hearts: 164 paroxysmal AF<\/jats:styled-content> patients and 164 age\u2010 and sex\u2010matched (1:1) controls. We calculated the DWS<\/jats:styled-content> from the M\u2010mode echocardiographic measurements of the LV<\/jats:styled-content> posterior wall thickness at end\u2010systole and end\u2010diastole during sinus rhythm.<\/jats:p><\/jats:sec>Results<\/jats:title>The DWS<\/jats:styled-content> was lower in the AF<\/jats:styled-content> patients (0.35\u2009\u00b1\u20090.07) than in the controls (0.41\u2009\u00b1\u20090.06; P<\/jats:italic> < 0.001). After adjusting for the risk factors of AF<\/jats:styled-content> using a conditional logistic regression analysis, a history of hypertension, plasma brain\u2010type natriuretic peptide level, and DWS<\/jats:styled-content> were independently associated with AF<\/jats:styled-content> prevalence, whereas body mass index, LV<\/jats:styled-content> mass index, left atrial volume, and any conventional indices of the diastolic function were not. A low DWS<\/jats:styled-content> (<0.380) was the strongest indicator of AF<\/jats:styled-content> (odds ratio: 6.22, 95% confidence interval: 3.08\u201014.2, P<\/jats:italic> < 0.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Increased LV<\/jats:styled-content> stiffness estimated by DWS<\/jats:styled-content> was a strong determinant of the prevalence of AF<\/jats:styled-content>. LV<\/jats:styled-content> stiffness may play a role in the pathogenesis of paroxysmal AF<\/jats:styled-content> in structurally normal hearts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22595","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T05:43:27Z","timestamp":1476337407000},"page":"728-732","source":"Crossref","is-referenced-by-count":13,"title":["Left ventricular stiffness estimated by diastolic wall strain is associated with paroxysmal atrial fibrillation in structurally normal hearts"],"prefix":"10.1002","volume":"39","author":[{"given":"Shunsuke","family":"Uetake","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School Chiba Hokusoh Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsunori","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School Chiba Hokusoh Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhito","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School Chiba Hokusoh Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School Chiba Hokusoh Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Seino","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School Chiba Hokusoh Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.946"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02373-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.09.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-1037"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.194"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12574-014-0238-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.2.724"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12574-014-0225-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510350050036"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs135"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031994"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.248"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22595","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:03:52Z","timestamp":1696604632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,7]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/clc.22595"],"URL":"https:\/\/doi.org\/10.1002\/clc.22595","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,7]]}}}