{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:30:18Z","timestamp":1776468618147,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The predictors of cardiovascular events in patients with chronic refractory angina are limited. High\u2010sensitivity cardiac troponin T (hs\u2010<jats:styled-content style=\"fixed-case\">cTnT<\/jats:styled-content>) assays are biomarkers that may be used to determine the prognosis of patients with stable coronary artery disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Hs\u2010<jats:styled-content style=\"fixed-case\">cTnT<\/jats:styled-content> is a predictor of death and nonfatal myocardial infarction (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) in patients with refractory angina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled 117 consecutive patients in this study. A heart team ruled out myocardial revascularization feasibility after assessing recent coronary angiograms; evidence of myocardial ischemia served as an inclusion criterion. Optimal medical therapy was encouraged via outpatient visits every 6 months; plasma hs\u2010<jats:styled-content style=\"fixed-case\">cTnT<\/jats:styled-content> levels were determined at baseline. The primary endpoint was the composite incidence of death and nonfatal <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up period of 28.0 months (interquartile range, 18.0\u201347.5 months), an estimated 28.0\u2010month cumulative event rate of 13.4% was determined via the Kaplan\u2010Meier method. Univariate predictors of the composite endpoint were hs\u2010<jats:styled-content style=\"fixed-case\">cTnT<\/jats:styled-content> levels and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dysfunction. Following a multivariate analysis, only hs\u2010<jats:styled-content style=\"fixed-case\">cTnT<\/jats:styled-content> was independently associated with the events in question, either as a continuous variable (hazard ratio per unit increase in the natural logarithm: 2.83, 95% confidence interval: 1.62\u20104.92, <jats:italic>P<\/jats:italic> &lt; 0.001) or as a categorical variable (hazard ratio for concentrations above the 99th percentile: 5.14, 95% confidence interval: 2.05\u201012.91, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with chronic refractory angina, plasma concentration of hs\u2010<jats:styled-content style=\"fixed-case\">cTnT<\/jats:styled-content> is the strongest predictor of death and nonfatal <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>. Notably, none of the outcomes in question occurred in patients with baseline plasma levels &lt;5.0 ng\/L.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22599","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T15:13:58Z","timestamp":1476803638000},"page":"11-17","source":"Crossref","is-referenced-by-count":9,"title":["A prospective study of patients with refractory angina: outcomes and the role of high\u2010sensitivity troponin T"],"prefix":"10.1002","volume":"40","author":[{"given":"Nilson T.","family":"Poppi","sequence":"first","affiliation":[{"name":"Refractory Angina Research Group, Heart Institute (InCor) University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Clinical Unit of Chronic Coronary Heart Disease InCor, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds H.W.","family":"Gowdak","sequence":"additional","affiliation":[{"name":"Refractory Angina Research Group, Heart Institute (InCor) University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Laboratory of Genetics and Molecular Cardiology InCor, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana O.C.","family":"Dourado","sequence":"additional","affiliation":[{"name":"Refractory Angina Research Group, Heart Institute (InCor) University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Clinical Unit of Chronic Coronary Heart Disease InCor, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo L.","family":"Adam","sequence":"additional","affiliation":[{"name":"Refractory Angina Research Group, Heart Institute (InCor) University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago N.P.","family":"Leite","sequence":"additional","affiliation":[{"name":"Refractory Angina Research Group, Heart Institute (InCor) University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno M.","family":"Mioto","sequence":"additional","affiliation":[{"name":"Clinical Unit of Chronic Coronary Heart Disease InCor, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 E.","family":"Krieger","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Molecular Cardiology InCor, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz A.M.","family":"C\u00e9sar","sequence":"additional","affiliation":[{"name":"Clinical Unit of Chronic Coronary Heart Disease InCor, University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of 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