{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T09:18:03Z","timestamp":1788081483308,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>About a decade past the first transcatheter aortic valve implantation (<jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content>), data are limited regarding temporal trends accompanying its evolution from novel technology to mainstream therapy. We evaluated these trends in a large multicenter <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> is changing and improving with time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> between January 2008 and December 2014 at 3 high\u2010volume Israeli centers were divided into 5 time quintiles according to procedure date. Outcomes were analyzed and reported according to Valve Academic Research Consortium\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1285 patients were studied (43% male; mean age, 83 \u00b1 3 years; mean Society of Thoracic Surgeons [<jats:styled-content style=\"fixed-case\">STS<\/jats:styled-content>] score, 5.5 \u00b1 3.6). Over time, there was a shift toward treating patients at lower <jats:styled-content style=\"fixed-case\">STS<\/jats:styled-content> score, increased use of conscious sedation and transfemoral approach, and decreased use of balloon predilatation. The balloon\u2010expandable to self\u2010expandable valve utilization ratio decreased, the valve\u2010in\u2010valve experience increased from 4% to 17% of all <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> volume, and length of hospital stay was halved (<jats:italic>P<\/jats:italic> = 0.006). Kaplan\u2010Meier survival curves showed gradual decrease in mortality risk (<jats:italic>P<\/jats:italic> = 0.031), but there was no significant 1\u2010year mortality decrease by multivariable analysis. Each year increment was associated with an adjusted 20%, 15%, and 12% decrease in new pacemaker obligation (<jats:italic>P<\/jats:italic> = 0.004), new pacemaker obligation or left bundle branch block (<jats:italic>P<\/jats:italic> = 0.008), and in\u2010hospital infections (<jats:italic>P<\/jats:italic> = 0.082), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Temporal trends accompanying <jats:styled-content style=\"fixed-case\">TAVI<\/jats:styled-content> evolution include its utilization in lower\u2010risk patients, procedural simplification, improved overall survival, decreased pacemaker obligation, and shorter hospital stay.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22632","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T16:23:14Z","timestamp":1477498994000},"page":"82-88","source":"Crossref","is-referenced-by-count":32,"title":["Temporal trends in transcatheter aortic valve implantation, 2008\u20132014: patient characteristics, procedural issues, and clinical outcome"],"prefix":"10.1002","volume":"40","author":[{"given":"Uri","family":"Landes","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Barsheshet","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Finkelstein","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tel Aviv Medical Center  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Guetta","sequence":"additional","affiliation":[{"name":"Leviev Heart Center, Sheba Medical Center  Ramat Gan Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University  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