{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:40:07Z","timestamp":1790073607863,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T00:00:00Z","timestamp":1482796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Complex multimarker approaches to predict outcome after <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u2010elevation myocardial infarction (<jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>) have only considered a single baseline sample, while neglecting easily obtainable peak creatine kinase and creatine kinase\u2010<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CK\u2010MB<\/jats:styled-content>) values during hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 476 patients undergoing primary percutaneous coronary intervention for <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content> and cardiac magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">CMRI<\/jats:styled-content>) at 4\u20106 months after <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>. We determined the association with cardiac biomarkers (peak <jats:styled-content style=\"fixed-case\">CK\u2010MB<\/jats:styled-content>, peak troponin T, N\u2010terminal pro\u2010brain natriuretic peptide), clinical and angiographic characteristics with infarct size, and <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>, followed by association with mortality in 1120 <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peak <jats:styled-content style=\"fixed-case\">CK\u2010MB<\/jats:styled-content> was the strongest predictor for infarct size (<jats:italic>P<\/jats:italic>&lt;0.001, <jats:italic>R<\/jats:italic>\n<jats:sup>2<\/jats:sup>=0.60) and LVEF (<jats:italic>P<\/jats:italic>&lt;0.001, <jats:italic>R<\/jats:italic>\n<jats:sup>2<\/jats:sup>=0.40). The additional value of clinical and angiographic characteristics was limited. The optimal peak CK\u2010MB cutpoints, for differentiation among small (&lt;10% of the left ventricle), moderate (\u226510%\u2013&lt;30%), and large infarct size (\u226530%), were 210 U\/L and 380 U\/L, respectively. These cutpoints were associated with 90\u2010day mortality; the hazard ratio for moderate infarct was 2.99 (95% confidence interval [CI]: 1.51\u20105.93, <jats:italic>P<\/jats:italic>=0.002) and for large infarct 6.53 (95% CI: 3.63\u201011.76, <jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Classical peak CK\u2010MB measured during hospitalization for STEMI was superior to other clinical and angiographic characteristics in predicting CMRI\u2010defined infarct size and LVEF, and should be included and validated in future multimarker studies. Peak CK\u2010MB cutpoints differentiated among infarct size categories and were associated with increased 90\u2010day mortality risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22663","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T12:43:40Z","timestamp":1482842620000},"page":"322-328","source":"Crossref","is-referenced-by-count":33,"title":["The contemporary value of peak creatine kinase\u2010<scp>MB<\/scp> after <scp>ST<\/scp>\u2010segment elevation myocardial infarction above other clinical and angiographic characteristics in predicting infarct size, left ventricular ejection fraction, and mortality"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-3259","authenticated-orcid":false,"given":"Minke H. T.","family":"Hartman","sequence":"first","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben N.","family":"Eppinga","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J. J.","family":"Vlaar","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris P. H.","family":"Lexis","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Lipsic","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost D. E.","family":"Haeck","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Academic Medical Center Amsterdam University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"van Veldhuisen","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwan C. C.","family":"van der Horst","sequence":"additional","affiliation":[{"name":"Department of Critical Care University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"van der Harst","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs033"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000036368.63317.1C"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes271"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.04.029"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.51.4.614"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22491"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.09.537"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.11.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.01.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-010-9209-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.12.011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-013-0977-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.053"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.187397"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs215"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.04.085"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2014.08.026"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.08.037"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.12.008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.08.010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.05.035"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.06.008"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22663","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:11:49Z","timestamp":1696637509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,27]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/clc.22663"],"URL":"https:\/\/doi.org\/10.1002\/clc.22663","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,27]]}}}