{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:17:32Z","timestamp":1777544252515,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T00:00:00Z","timestamp":1484092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Heart and Stroke Foundation of Canada"},{"name":"The Academic Development Fund, Western University, London, ON, Canada"},{"name":"Lawson Health Research Institute, London, ON, Canada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>The clinical value of ischemic conditioning during percutaneous coronary intervention (<jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>) and mode of administration is controversial. Our aim was to assess the long\u2010term effect of remote ischemic postconditioning among patients undergoing <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>. We randomized 360 patients undergoing <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> who presented with a negative troponin T at baseline into 3 groups: 2 groups received remote ischemic postconditioning (with ischemia applied to the arm in 1 group and to the thigh in the other group), and the third group acted as a control group. Remote ischemic postconditioning was applied during <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> immediately following stent deployment, by 3, 5\u2010minute cycles of blood pressure cuff inflation to &gt;200 mm Hg on the arm or thigh (20 mm Hg to the arm in the control), with 5\u2010minute breaks between each cycle. There were no differences in baseline characteristics among the 3 groups. Periprocedural myocardial injury occurred in 33% (<jats:italic>P<\/jats:italic> = 0.64). After 1 year, there was no difference between groups in death (<jats:italic>P<\/jats:italic> = 0.91), myocardial infarction (<jats:italic>P<\/jats:italic> = 0.78), or repeat revascularization (<jats:italic>P<\/jats:italic> = 0.86). During 3 years of follow\u2010up, there was no difference in death, myocardial infarction, and revascularization among the groups (<jats:italic>P<\/jats:italic> = 0.45). Remote ischemic postconditioning during <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> did not affect long\u2010term cardiovascular outcome. A similar effect was obtained when remote ischemia was induced to the upper or lower limb.<\/jats:p><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> Identifier: NCT00970827<\/jats:p>","DOI":"10.1002\/clc.22668","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T15:51:01Z","timestamp":1484149861000},"page":"268-274","source":"Crossref","is-referenced-by-count":10,"title":["Long\u2010term outcome following remote ischemic postconditioning during percutaneous coronary interventions\u2014the <scp>RIP\u2010PCI<\/scp> trial long\u2010term follow\u2010up"],"prefix":"10.1002","volume":"40","author":[{"given":"Shahar","family":"Lavi","sequence":"first","affiliation":[{"name":"Western University  London Ontario Canada"},{"name":"London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour","family":"Abu\u2010Romeh","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Wall","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mistre","family":"Alemayehu","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Lavi","sequence":"additional","affiliation":[{"name":"Western University  London Ontario Canada"},{"name":"London Health Sciences Centre  London Ontario 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