{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:11:56Z","timestamp":1788289916867,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Repeated exposure to intermittent normobaric hypoxia improves exercise tolerance in cardiac patients. Little is known on the effects of intermittent normobaric hypoxia\u2010hyperoxia exposure in coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) patients (New York Heart Association <jats:styled-content style=\"fixed-case\">II\u2013III<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">IHHT<\/jats:styled-content> improves exercise tolerance, cardiometabolic profile, and quality of life in <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study design was a nonrandomized, controlled, before\u2010and\u2010after trial. Forty\u2010six <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients volunteered to take part in the study: a group of 27 patients undertook the intermittent hypoxia (<jats:styled-content style=\"fixed-case\">O<jats:sub>2<\/jats:sub>\n<\/jats:styled-content> at 10%)\u2013hyperoxia (<jats:styled-content style=\"fixed-case\">O<jats:sub>2<\/jats:sub>\n<\/jats:styled-content> at 30%) training (<jats:styled-content style=\"fixed-case\">IHHT<\/jats:styled-content>), whereas a control group (<jats:styled-content style=\"fixed-case\">CTRL<\/jats:styled-content>) of 19 patients, who already completed an 8\u2010week standard cardiac rehabilitation program, was allocated to sham\u2010<jats:styled-content style=\"fixed-case\">IHHT<\/jats:styled-content> treatment (breathing room air, <jats:styled-content style=\"fixed-case\">O<jats:sub>2<\/jats:sub>\n<\/jats:styled-content> at 21%). Exercise performance, blood and metabolic profiles, and quality of life (Seattle Angina Questionnaire [<jats:styled-content style=\"fixed-case\">SAQ<\/jats:styled-content>]) were measured before and after in the <jats:styled-content style=\"fixed-case\">IHHT<\/jats:styled-content> group (<jats:styled-content style=\"fixed-case\">IHHG<\/jats:styled-content>) and sham\u2010<jats:styled-content style=\"fixed-case\">IHHT<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">CTRL<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">IHHG<\/jats:styled-content> showed improved exercise capacity, reduced systolic and diastolic blood pressures, enhanced left ventricle ejection fraction, and reduced glycemia, but only at 1\u2010month follow\u2010up. Angina as a reason to stop exercising was significantly reduced after treatment and at 1\u2010month follow\u2010up. The <jats:styled-content style=\"fixed-case\">IHHT SAQ<\/jats:styled-content> profile was improved in the <jats:styled-content style=\"fixed-case\">IHHG<\/jats:styled-content> and not significantly different to the <jats:styled-content style=\"fixed-case\">CTRL<\/jats:styled-content> group after standard rehabilitation. The <jats:styled-content style=\"fixed-case\">IHHG<\/jats:styled-content> was also compared to the <jats:styled-content style=\"fixed-case\">CTRL<\/jats:styled-content> group at 1\u2010month follow\u2010up, and no differences were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients, an <jats:styled-content style=\"fixed-case\">IHHT<\/jats:styled-content> program is associated with improved exercise tolerance, healthier risks factors profile, and a better quality of life. Our study also suggests that <jats:styled-content style=\"fixed-case\">IHHT<\/jats:styled-content> is as effective as an 8\u2010week standard rehabilitation program.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22670","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T07:18:18Z","timestamp":1490167098000},"page":"370-376","source":"Crossref","is-referenced-by-count":60,"title":["Adaptations following an intermittent hypoxia\u2010hyperoxia training in coronary artery disease patients: a controlled study"],"prefix":"10.1002","volume":"40","author":[{"given":"Oleg","family":"Glazachev","sequence":"first","affiliation":[{"name":"I. M. Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phylipp","family":"Kopylov","sequence":"additional","affiliation":[{"name":"I. M. Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Susta","sequence":"additional","affiliation":[{"name":"School of Health and Human Performance Dublin City University  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Dudnik","sequence":"additional","affiliation":[{"name":"I. M. Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zagaynaya","sequence":"additional","affiliation":[{"name":"I. M. 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