{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:21:45Z","timestamp":1760955705457,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Introduction<\/jats:title>Dofetilide is a class III<\/jats:styled-content> antiarrhythmic prescribed to cardiovert persistent atrial fibrillation (AF<\/jats:styled-content>) to sinus rhythm (SR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>To determine the clinical predictors of cardioversion and readmission in persistent AF<\/jats:styled-content> patients on dofetilide.<\/jats:p><\/jats:sec>Methods<\/jats:title>We analyzed 160 patients with persistent AF<\/jats:styled-content> who were started on dofetilide and followed for 1 year. We examined age, sex, race, hypertension, diabetes, smoking, dyslipidemia, CAD<\/jats:styled-content>, left ventricular ejection fraction (LVEF<\/jats:styled-content>), creatinine, BMI<\/jats:styled-content> and concomitant use of calcium channel blockers (CCB<\/jats:styled-content>), \u03b2\u2010blockers in a multivariable logistic regression model. We also examined the same predictors in Cox regression model for AF<\/jats:styled-content>\u2010related readmission within 1 year of follow\u2010up.<\/jats:p><\/jats:sec>Results<\/jats:title>13.5% individuals did not convert to SR<\/jats:styled-content> on dofetilide. 55.6% converted on the first dose and 83.1% converted by the fourth dose. In multivariable logistic models, dyslipidemia (OR<\/jats:styled-content>: 2.4, CI<\/jats:styled-content>: 1.12\u20105.16) and LVEF<\/jats:styled-content> (OR<\/jats:styled-content>: 3.83,CI<\/jats:styled-content>: 1.37\u201010.8) were associated with failure to convert with the first dose. Female sex and LVEF<\/jats:styled-content> also were associated with increased risk of failure to convert at all. Concomitant use of CCB<\/jats:styled-content> associated with decreased risk of failure to convert to SR<\/jats:styled-content>. In Cox proportional model, female sex, age <63\u2009years and CAD<\/jats:styled-content> were associated with increased AF<\/jats:styled-content> readmission within 1 year.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Dyslipidemia and LVEF<\/jats:styled-content> <40% were associated with failure to cardiovert after first dose, and female sex and LVEF<\/jats:styled-content> 40% were related to failure to convert at all on dofetilide in persistent AF<\/jats:styled-content> patients. After 1\u2010year follow\u2010up, female sex, known CAD<\/jats:styled-content>, and age <63\u2009years were associated with increased AF<\/jats:styled-content> readmissions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22680","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T21:13:11Z","timestamp":1489525991000},"page":"474-479","source":"Crossref","is-referenced-by-count":5,"title":["Short\u2010 and long\u2010term clinical predictors of pharmacological cardioversion of persistent atrial fibrillation by dofetilide: A retrospective cohort study of 160 patients"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-942X","authenticated-orcid":false,"given":"Hafeez Ul","family":"Hassan Virk","sequence":"first","affiliation":[{"name":"ACAP Cardiac Research Program, Al\u2010Sabah Arrhythmia Institute, Division of Cardiology Mount Sinai St. Luke's and Mount Sinai West Hospitals New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5189-4417","authenticated-orcid":false,"given":"Waqas T.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayani","family":"Makkar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Bastawrose","sequence":"additional","affiliation":[{"name":"ACAP Cardiac Research Program, Al\u2010Sabah Arrhythmia Institute, Division of Cardiology Mount Sinai St. Luke's and Mount Sinai West Hospitals New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nektarios","family":"Souvaliotis","sequence":"additional","affiliation":[{"name":"ACAP Cardiac Research Program, Al\u2010Sabah Arrhythmia Institute, Division of Cardiology Mount Sinai St. Luke's and Mount Sinai West Hospitals New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Aziz","sequence":"additional","affiliation":[{"name":"ACAP Cardiac Research Program, Al\u2010Sabah Arrhythmia Institute, Division of Cardiology Mount Sinai St. Luke's and Mount Sinai West Hospitals New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad","family":"Aziz","sequence":"additional","affiliation":[{"name":"ACAP Cardiac Research Program, Al\u2010Sabah Arrhythmia Institute, Division of Cardiology Mount Sinai St. Luke's and Mount Sinai West Hospitals New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595140"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs469"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2012.12.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.9.819"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.958165"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.051"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.018"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.10.001"},{"key":"e_1_2_6_10_1","unstructured":"Center for Drug Evaluation and Research US Food and Drug Administration. Tikosyn (dofetilide) NDA approval letter. Available at:http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/99\/20-931_Tikosyn_Approv.pdf. Dated October 1 1999. Accessed April 26 2012."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.19.2385"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:CEPR.0000012386.82055.81"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-004-0002-y"},{"key":"e_1_2_6_14_1","first-page":"1633","article-title":"Conversion of atrial fibrillation and maintenance of sinus rhythm by dofetilide: the EMERALD (European and Australian Multicenter Evaluative Research on Atrial Fibrillation Dofetilide) study","volume":"98","author":"Greenbaum RA","year":"1998","journal-title":"Circulation."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909163411201"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03402-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.002339"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:04:27Z","timestamp":1696637067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/clc.22680"],"URL":"https:\/\/doi.org\/10.1002\/clc.22680","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"type":"print","value":"0160-9289"},{"type":"electronic","value":"1932-8737"}],"subject":[],"published":{"date-parts":[[2017,3,14]]}}}