{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:30:58Z","timestamp":1763037058399,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The present European guidelines suggest a diagnostic electrophysiological (<jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content>) study to determine indication for cardiac pacing in patients with bundle branch block and unexplained syncope. We evaluated the prognostic relevance of an <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> study for mortality and the development of permanent complete atrioventricular (<jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>) block in patients with symptomatic bifascicular block and first\u2010degree <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> block.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The HV interval is a poor prognostic marker to predict the development of permanent AV block in patients with symptomatic bifascicular block (BFB) and AV block I\u00b0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty consecutive patients (mean age, 74.8 \u00b1 8.6 years; 25 males) with symptomatic <jats:styled-content style=\"fixed-case\">BFB<\/jats:styled-content> and first\u2010degree <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> block underwent an <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> study before device implantation, according to current guidelines. For 53 \u00b1 31 months, patients underwent yearly follow\u2010up screening for syncope or higher\u2010degree <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> block.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients presented with prolonged <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content> interval during the <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> study (mean, 82.2 \u00b1 20.1 ms; range, 57\u2013142 ms), classified into 3 groups: group 1, &lt;70 ms (mean, 62 \u00b1 4 ms; range, 57\u201367 ms; n = 7), group 2, &gt;70 to \u2264100 ms (mean, 80 \u00b1 8 ms; range, 70\u201397 ms; n = 18), and group 3, &gt;100 ms (mean, 119 \u00b1 14 ms; range, 107\u2013142 ms; n = 5). According to the guidelines, patients in groups 2 and 3 received a pacemaker. The length of the <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content> interval was not associated with the later development of third\u2010degree <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> block or with increased mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our present study suggests that an indication for pacemaker implantation based solely on a diagnostic <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> study with prolongation of the <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content> interval is not justified.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22700","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T12:11:09Z","timestamp":1489579869000},"page":"575-579","source":"Crossref","is-referenced-by-count":9,"title":["Is there a prognostic relevance of electrophysiological studies in bundle branch block patients?"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-630X","authenticated-orcid":false,"given":"Harilaos","family":"Bogossian","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology L\u00fcdenscheid Clinic, M\u00e4rkische Clinics GmbH  L\u00fcdenscheid Germany"},{"name":"Department of Cardiology Witten\/Herdecke University  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrit","family":"Frommeyer","sequence":"additional","affiliation":[{"name":"Division of Electrophysiology, Department of Cardiovascular Medicine University of M\u00fcnster  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kornelius","family":"G\u00f6bbert","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology L\u00fcdenscheid Clinic, M\u00e4rkische Clinics GmbH  L\u00fcdenscheid Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuad","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology L\u00fcdenscheid Clinic, M\u00e4rkische Clinics GmbH  L\u00fcdenscheid Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quy Suu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology L\u00fcdenscheid Clinic, M\u00e4rkische Clinics GmbH  L\u00fcdenscheid Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Ninios","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology L\u00fcdenscheid Clinic, M\u00e4rkische Clinics GmbH  L\u00fcdenscheid Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejan","family":"Mijic","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology L\u00fcdenscheid Clinic, M\u00e4rkische Clinics GmbH  L\u00fcdenscheid Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Bandorski","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology L\u00fcdenscheid Clinic, M\u00e4rkische Clinics GmbH  L\u00fcdenscheid Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Hoeltgen","sequence":"additional","affiliation":[{"name":"Medical Clinic\u2013Cardiology\/Electrophysiology, Westm\u00fcnsterland Clinic St. Agnes\u2010Hospital Bocholt I  Bocholt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melchior","family":"Seyfarth","sequence":"additional","affiliation":[{"name":"Department of Cardiology HELIOS University Hospital Wuppertal  Germany"},{"name":"Department of Cardiology Witten\/Herdecke University  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Lemke","sequence":"additional","affiliation":[{"name":"Department of 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