{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:58:37Z","timestamp":1784552317107,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Coronary artery aneurysm is defined as a coronary dilation that exceeds the diameter of adjacent segments or the diameter of the patient's largest normal coronary vessel by 1.5\u00d7. It is an uncommon disease that has been diagnosed with increasing frequency since the widespread appearance of coronary angiography. The published incidence varies from 1.5% to 5%, suggesting male dominance and a predilection for the right coronary artery. Although several causes have been described, atherosclerosis accounts for \u226550% of coronary aneurysms in adults. Reported complications include thrombosis and distal embolization, rupture, and vasospasm, causing ischemia, heart failure, or arrhythmias. The natural history and prognosis remain unknown, as definitive data are scarce. Controversies persist regarding the use of medical management (antithrombotic therapy) or interventional\/surgical procedures. Only some case reports or small case series are available about this condition. The Coronary Artery Aneurysm Registry (<jats:styled-content style=\"fixed-case\">CAAR<\/jats:styled-content>; <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ClinicalTrials.gov\">http:\/\/www.ClinicalTrials.gov<\/jats:ext-link> <jats:styled-content style=\"fixed-case\">NCT02563626<\/jats:styled-content>) is a multicenter international ambispective registry that aims to provide insights on anatomic, epidemiologic, and clinical aspects of this substantially unknown entity. In addition, the registry will assess management strategies (conservative, interventional, or surgical) and their short\u2010 and long\u2010term results in a large cohort of patients.<\/jats:p><jats:p>Clinical Trial registration: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>. Unique identifier: <jats:styled-content style=\"fixed-case\">NCT02563626<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/clc.22705","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T08:25:38Z","timestamp":1490343938000},"page":"580-585","source":"Crossref","is-referenced-by-count":21,"title":["Rationale and design of a multicenter, international and collaborative Coronary Artery Aneurysm Registry (<scp>CAAR<\/scp>)"],"prefix":"10.1002","volume":"40","author":[{"given":"Iv\u00e1n J.","family":"N\u00fa\u00f1ez\u2010Gil","sequence":"first","affiliation":[{"name":"Cardiovascular Institute Hospital Cl\u00ednico San Carlos and Department of Medicine, Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Nombela\u2010Franco","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute Hospital Cl\u00ednico San Carlos and Department of Medicine, Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Bagur","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, London Health Sciences Centre, and Department of Epidemiology and Biostatistics Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Bollati","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology SS Annanziata Hospital  Savigliano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Cerrato","sequence":"additional","affiliation":[{"name":"Interventional Unit, San Luigi Gonzaga University Hospital Orbassano and Infermi HOspital  Rivoli (Turin) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Instituto de Cardiolog\u00eda y Cirug\u00eda Cardiovascular  La Habana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Liebetrau","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhein\u2010Main  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"De la Torre Hernandez","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjam\u00edn","family":"Camacho","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital Arnau de Vilanova  L\u00e9rida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Mila","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital de Cl\u00ednicas Dr. Manuel Quintela  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio J.","family":"Amat\u2010Santos","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital Cl\u00ednico Universitario de Valladolid  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Alfonso","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Rodr\u00edguez\u2010Olivares","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology University Medical Center Utrecht  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago J.","family":"Camacho Freire","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital Juan Ram\u00f3n Jim\u00e9nez  Huelva Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cd\u00f1igo","family":"Lozano","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital de Cabue\u00f1es  Gijon Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Alfonso","family":"Jim\u00e9nez D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital \u00c1lvaro Cunqueiro  Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Piraino","sequence":"additional","affiliation":[{"name":"UO di Cardiologia Interventistica ed Hemodin\u00e1mica Azienda Ospedaliera Universitaria Policlinico \u201cP. 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