{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T21:05:02Z","timestamp":1784667902077,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetes mellitus (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>) is associated with adverse outcomes after surgical aortic valve replacement. However, there are conflicting data on the impact of <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> on outcomes of transcatheter aortic valve replacement (<jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> is associated with poor outcomes after different cardiac procedures. Therefore, <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> can also be associated with poor outcomes after <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched <jats:styled-content style=\"fixed-case\">PubMed<\/jats:styled-content> and Cochrane Central Register of Controlled Trials for studies that evaluated outcomes after <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content> and stratified at least 1 of the studied endpoints by <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> status. The primary endpoint was all\u2010cause mortality at 1 year. Secondary endpoints were early (up to 30 days) mortality, acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>), cerebrovascular accident (<jats:styled-content style=\"fixed-case\">CVA<\/jats:styled-content>), major bleeding, and major vascular complications. Pooled odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) and 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) were calculated using random effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 64 studies with a total of 38\u2009686 patients. <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> was associated with significantly higher 1\u2010year mortality (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.14, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.04\u20101.26, <jats:italic>P<\/jats:italic> = 0.008) and periprocedural <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.28, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.08\u20101.52, <jats:italic>P<\/jats:italic> = 0.004). On the other hand, there were no significant differences between diabetics and nondiabetics in early mortality, <jats:styled-content style=\"fixed-case\">CVAs<\/jats:styled-content>, major bleeding, or major vascular complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> is associated with increased 1\u2010year mortality and periprocedural <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> in patients undergoing <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>. The results of this study suggest that <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> is a predictor of adverse outcomes in patients undergoing <jats:styled-content style=\"fixed-case\">TAVR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22723","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T13:13:05Z","timestamp":1494940385000},"page":"726-731","source":"Crossref","is-referenced-by-count":28,"title":["Diabetes mellitus is associated with increased acute kidney injury and 1\u2010year mortality after transcatheter aortic valve replacement: A meta\u2010analysis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1638-7620","authenticated-orcid":false,"given":"George S.","family":"Mina","sequence":"first","affiliation":[{"name":"Department of Cardiology Louisiana State University Health Sciences Center\u2013Shreveport  Shreveport Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Cardiology Louisiana State University Health Sciences Center\u2013Shreveport  Shreveport Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demiana","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Louisiana State University Health Sciences Center\u2013Shreveport  Shreveport Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratap","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Cardiology Louisiana State University Health Sciences Center\u2013Shreveport  Shreveport Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paari","family":"Dominic","sequence":"additional","affiliation":[{"name":"Department of Cardiology Louisiana State University Health Sciences Center\u2013Shreveport  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