{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:04:20Z","timestamp":1776474260236,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Thromboembolic complications can be life\u2010threatening during atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) catheter ablation. The aim of our study was to evaluate the safety and efficacy of continuous treatment using direct oral anticoagulants (<jats:styled-content style=\"fixed-case\">DOACs<\/jats:styled-content>) as an alternative to uninterrupted acenocoumarol for periprocedural anticoagulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Continuous treatment with DOACs has similar safety and efficacy compared to acenocoumarol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 474 patients (mean age, 58 years; 68.4% male) undergoing <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> catheter ablation between June 2013 and December 2016. All patients were equally assigned to take acenocoumarol (group 1, 136 patients) or <jats:styled-content style=\"fixed-case\">DOACs<\/jats:styled-content> (group 2, 338 patients) for \u22652 months before the procedure. We compared thromboembolic and bleeding complications between the 2 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our analysis showed no significant difference in major and minor complications between the 2 patient groups. Specifically, 3 of 136 patients (2.2%) using uninterrupted acenocoumarol had a major complication (1 patient [0.7%] had transient ischemic attack resolved 8 hours later, 1 [0.7%] had pericardial tamponade, and 1 [0.7%] had a subcapsular renal hematoma) and 2 patients (1.4%) had minor complications (1 [0.7%] pseudoaneurysm and 1 [0.7%] groin hematoma). In group 2, 1 of 338 patients (0.3%) had a major complication (transient ischemic attack). In the same group, 7 patients (2.1%) had a minor complication (1 patient [0.3%] presented with pseudoaneurysm, 4 [1.2%] with pericardial effusion &lt;1 cm, 1 [0.3%] femoral arteriovenous fistula between the femoral artery and femoral vein, and 1 [0.7%] groin hematoma).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DOACs<\/jats:styled-content> and acenocoumarol have similar safety and effectiveness regarding thromboembolic complications prevention without increasing bleeding complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22734","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T13:57:09Z","timestamp":1496239029000},"page":"847-852","source":"Crossref","is-referenced-by-count":10,"title":["Safety and efficacy of <scp>DOACs<\/scp> vs acenocoumarol in patients undergoing catheter ablation of atrial fibrillation"],"prefix":"10.1002","volume":"40","author":[{"given":"Konstantinos","family":"Vlachos","sequence":"first","affiliation":[{"name":"Laboratory of Cardiac Electrophysiology \u201cEvangelismos\u201d General Hospital of Athens  Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Efremidis","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiac Electrophysiology \u201cEvangelismos\u201d General Hospital of Athens  Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-9772","authenticated-orcid":false,"given":"George","family":"Bazoukis","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiac Electrophysiology \u201cEvangelismos\u201d General Hospital of Athens  Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos P.","family":"Letsas","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiac Electrophysiology 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