{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:19:53Z","timestamp":1787163593880,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>\n                    The role of electrocardiography (ECG) in prognosticating pulmonary embolism (PE) is increasingly recognized. ECG is quickly interpretable, noninvasive, inexpensive, and available in remote areas. We hypothesized that ECG can provide useful information about PE prognostication. We searched MEDLINE, EMBASE, Google Scholar, Web of Science, abstracts, conference proceedings, and reference lists through February 2017. Eligible studies used ECG to prognosticate for the main outcomes of death and clinical deterioration or escalation of therapy. Two authors independently selected studies; disagreement was resolved by consensus. Ad hoc piloted forms were used to extract data and assess risk of bias. We used a random\u2010effects model to pool relevant data in meta\u2010analysis with odds ratios (ORs) and 95% confidence intervals (CIs); all other data were synthesized qualitatively. Statistical heterogeneity was assessed using the\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sup>\n                    value. We included 39 studies (9198 patients) in the systematic review. There was agreement in study selection (\u03ba: 0.91, 95% CI: 0.86\u20100.96). Most studies were retrospective; some did not appropriately control for confounders. ECG signs that were good predictors of a negative outcome included S1Q3T3 (OR: 3.38, 95% CI: 2.46\u20104.66,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), complete right bundle branch block (OR: 3.90, 95% CI: 2.46\u20106.20,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), T\u2010wave inversion (OR: 1.62, 95% CI: 1.19\u20102.21,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.002), right axis deviation (OR: 3.24, 95% CI: 1.86\u20105.64,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001), and atrial fibrillation (OR: 1.96, 95% CI: 1.45\u20102.67,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001) for in\u2010hospital mortality. Several ischemic patterns also were significantly predictive. Our conclusion is that ECG is potentially valuable in prognostication of acute PE.\n                  <\/jats:p>","DOI":"10.1002\/clc.22742","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T09:34:40Z","timestamp":1497864880000},"page":"814-824","source":"Crossref","is-referenced-by-count":54,"title":["The value of electrocardiography in prognosticating clinical deterioration and mortality in acute pulmonary embolism: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-9201","authenticated-orcid":false,"given":"Amro","family":"Qaddoura","sequence":"first","affiliation":[{"name":"Department of Medicine, Kingston General Hospital Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve C.","family":"Digby","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kingston General Hospital Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Kabali","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Kukla","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Internal Medicine Specialistic Hospital  Gorlice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong\u2010Qun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Taihe Hospital Hubei University of Medicine  Shiyan City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian M.","family":"Baranchuk","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kingston General Hospital Queen's University  Kingston Ontario 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