{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:57:22Z","timestamp":1790650642088,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The oxygen (O<jats:sub>2<\/jats:sub>) pulse curve obtained at cardiopulmonary exercise testing provides information on cardiorespiratory fitness and the presence of cardiovascular disease. O<jats:sub>2<\/jats:sub> pulse abnormalities have been attributed to myocardial ischemia, among other conditions, but the predictors of abnormal O<jats:sub>2<\/jats:sub> pulse curves are not completely known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Perfusion abnormalities detected by myocardial perfusion scintigraphy (MPS) may be associated with abnormal O<jats:sub>2<\/jats:sub> pulse curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients with normal left ventricular function underwent cardiopulmonary exercise testing with radiotracer injection at peak exercise, followed by MPS. The O<jats:sub>2<\/jats:sub> pulse curves were classified as (A) normal; (B) probably normal (normal slope with lower peak value); (C) probably abnormal (flat, with low peak value); or (D) definitely abnormal (descending slope), and analyzed as A\/B vs C\/D. Coronary artery disease (CAD) was defined as &gt;50% stenosis. MPS perfusion scores were calculated (summed rest score [SRS], indicating myocardial fibrosis; summed difference score, indicating ischemia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparing patients with A\/B vs C\/D curves, the latter were more frequently female and had higher SRS. The prevalence of ischemic MPS, of any CAD, or multivessel CAD was not significantly different among patients with A\/B or C\/D curve patterns. On logistic regression, female sex, body mass index, and the SRS were significantly associated with C\/D curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Female sex, increasing body mass index, and myocardial fibrosis were significant predictors of abnormal O<jats:sub>2<\/jats:sub> pulse curves. Myocardial ischemia and the presence and extent of CAD were not associated with the abnormal patterns of the O<jats:sub>2<\/jats:sub> pulse curve.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22747","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T16:42:37Z","timestamp":1499272957000},"page":"914-918","source":"Crossref","is-referenced-by-count":17,"title":["Clinical, scintigraphic, and angiographic predictors of oxygen pulse abnormality in patients undergoing cardiopulmonary exercise testing"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8522-6612","authenticated-orcid":false,"given":"Andrea","family":"De Lorenzo","sequence":"first","affiliation":[{"name":"Federal University of Rio de Janeiro, National Institute of Cardiology Instituto Estadual de Cardiologia Aloysio de Castro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlito Lessa","family":"da Silva","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro, National Institute of Cardiology Instituto Estadual de Cardiologia Aloysio de Castro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Cesar Castro","family":"Souza","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro, National Institute of Cardiology Instituto Estadual de Cardiologia Aloysio de Castro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Serra","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro, National Institute of Cardiology Instituto Estadual de Cardiologia Aloysio de Castro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Marino","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro, National Institute of Cardiology Instituto Estadual de Cardiologia Aloysio de Castro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo","family":"SL Lima","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro, National Institute of Cardiology Instituto Estadual de Cardiologia Aloysio de Castro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,5]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization. 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