{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:01:16Z","timestamp":1762113676746},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Geschwister-Kessel-Stiftung, Langenenslingen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Background<\/jats:title>Risk prediction in patients with severe aortic stenosis (AS<\/jats:styled-content>) undergoing transcatheter aortic valve implantation (TAVI<\/jats:styled-content>) is challenging. Development of novel markers for patient risk assessment is of great clinical value. Deceleration capacity (DC<\/jats:styled-content>) of heart rate is a strong risk predictor in post\u2010infarction patients.<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>DC<\/jats:styled-content> provides prognostic information in patients undergoing TAVI<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We enrolled 374 consecutive patients with severe AS<\/jats:styled-content> undergoing TAVI<\/jats:styled-content>. All patients received 24\u2010hour Holter recording or continuous heart\u2010rate monitoring to assess DC<\/jats:styled-content> before intervention. Primary endpoint was all\u2010cause mortality after 1 year.<\/jats:p><\/jats:sec>Results<\/jats:title>Forty\u2010nine patients (13.1%) died within 1 year. DC<\/jats:styled-content> was significantly lower in nonsurvivors than in survivors (1.2 \u00b1 4.8 ms vs 3.3 \u00b1 2.9 ms; P<\/jats:italic> < 0.001), whereas the logistic EuroSCORE<\/jats:styled-content> and EuroSCORE II<\/jats:styled-content> were comparable between groups (logistic EuroSCORE<\/jats:styled-content>: 27.3% \u00b1 17.0% vs 22.9% \u00b1 14.2%; P<\/jats:italic> = 0.122; EuroSCORE II<\/jats:styled-content>: 8.0% \u00b1 6.9% vs 6.7% \u00b1 4.8%, P<\/jats:italic> = 0.673). One\u2010year mortality in the 116 patients with impaired DC<\/jats:styled-content> (<2.5 ms) was significantly higher than in patients with normal DC<\/jats:styled-content> (23.3% vs 8.5%; P<\/jats:italic> < 0.001). In multivariate Cox regression analysis that included DC<\/jats:styled-content>, sex, paroxysmal atrial fibrillation, hemoglobin level before TAVI<\/jats:styled-content>, and logistic EuroSCORE<\/jats:styled-content>, DC<\/jats:styled-content> was the strongest predictor of 1\u2010year mortality (hazard ratio: 0.88, 95% confidence interval: 0.85\u20100.94, P<\/jats:italic> < 0.001). DC<\/jats:styled-content> yielded an AUC<\/jats:styled-content> in the ROC<\/jats:styled-content> analysis of 0.645.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>DC<\/jats:styled-content> of heart rate is a strong and independent predictor of 1\u2010year mortality in patients with severe AS<\/jats:styled-content> undergoing TAVI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22748","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T16:56:46Z","timestamp":1503939406000},"page":"919-924","source":"Crossref","is-referenced-by-count":17,"title":["Deceleration capacity of heart rate predicts 1\u2010year mortality of patients undergoing transcatheter aortic valve implantation"],"prefix":"10.1002","volume":"40","author":[{"given":"Martin","family":"Duckheim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Department of Cardiology Eberhard Karls University of T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Bensch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Department of Cardiology Eberhard Karls University of T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linn","family":"Kittlitz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Department of Cardiology Eberhard Karls University of T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nin","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Department of Cardiology Eberhard Karls University of T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Klee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Department of Cardiology Eberhard Karls University of T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Groga\u2010Bada","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Department of Cardiology Eberhard Karls University of T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Mizera","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Department of Cardiology Eberhard Karls University of T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinrad","family":"Gawaz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Department of Cardiology Eberhard Karls University of T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Zuern","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Department of Cardiology Eberhard Karls University of T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Eick","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Department of Cardiology Eberhard Karls University of T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.6.721"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00201-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047200.36165.B8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs455"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.537"},{"key":"e_1_2_6_7_1","first-page":"167","article-title":"Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio\u2010Thoracic Surgery (EACTS) [article in Italian]","volume":"14","author":"Vahanian A","year":"2013","journal-title":"G Ital Cardiol (Rome)"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00799-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp575"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e3283638e26"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.07.088"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn540"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.04.017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68735-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000922"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12107"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.01.028"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physa.2005.08.080"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs043"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.08.012"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005479"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2013.09.001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.2.211"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2014-000170"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(00)00173-X"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY15M11_12"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T20:18:46Z","timestamp":1695759526000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,28]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/clc.22748"],"URL":"https:\/\/doi.org\/10.1002\/clc.22748","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,28]]}}}