{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:39:57Z","timestamp":1790397597129,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002457","name":"Chosun University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2016R1D1A1B03932488"],"award-info":[{"award-number":["2016R1D1A1B03932488"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>CHADS<jats:sub>2<\/jats:sub> (congestive heart failure, hypertension, age \u2265 75 years, diabetes mellitus, stroke) and CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc (congestive heart failure, hypertension, age \u2265 75 years, diabetes mellitus, stroke, vascular disease, age 65 to 74 years, sex category) scores showed just moderate discrimination ability in predicting thromboembolic complications in patients with nonvalvular atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>To determine the association of antithrombin III (AT\u2010III) deficiency and mean platelet volume (MPV) with the development of stroke or left atrial (LA) thrombus in patients with AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AT\u2010III and MPV were analyzed in 352 patients with AF. The primary endpoint was a composite of ischemic stroke event and incidental LA thrombus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 50 events (14.2%) during a mean 35.4 months of follow\u2010up. A significantly higher stroke or LA thrombus rate was observed in the low\u2013AT\u2010III group (&lt;70%) than that in the high\u2013AT\u2010III group (\u226570%). A significantly higher stroke or LA thrombus rate was observed in the high\u2010MPV group (\u22657.0 fL) than that in the low\u2010MPV group (&lt;7.0 fL). AF patients with an MPV \u22657.0 fL and AT\u2010III deficiency had higher stroke or LA thrombus risk than those without an MPV \u22657.0 fL and AT\u2010III deficiency. In the Cox proportional hazard analysis, high MPV was found to be an independent predictor of stroke or LA thrombus risk (hazard ratio: 6.408; 95% confidence interval: 2.874\u201014.286). Although AT\u2010III deficiency was not an independent predictor of stroke or LA thrombus risk, a trend was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High MPV and AT\u2010III deficiency were predictive markers for stroke or LA thrombus. Their predictive power for stroke was independent of antiplatelet treatment, anticoagulation therapy, and a high CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score in patients with AF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22759","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T14:46:46Z","timestamp":1502722006000},"page":"1013-1019","source":"Crossref","is-referenced-by-count":20,"title":["Stroke or left atrial thrombus prediction using antithrombin III and mean platelet volume in patients with nonvalvular atrial fibrillation"],"prefix":"10.1002","volume":"40","author":[{"given":"Seo\u2010Won","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Cardiology Gwangju Veterans Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chosun University School of 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