{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:53:07Z","timestamp":1740145987302,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation (AF) burden and duration are predictors of thromboembolic events. The random nature of these measures may affect clinical decision making. The objective of this study was to determine temporal changes in AF burden as detected by continuous monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>AF burden changes over time when detected by continuous monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A post hoc analysis of patients enrolled in the TRENDS (A Prospective Study of the Clinical Significance of Atrial Arrhythmias Detected by Implanted Device Diagnostics) study with \u22651 stroke risk factor(s) who were implanted with a dual\u2010chamber cardiac rhythm management device (CRMD) and had AF burden data available for \u22652 years was performed. AF burden was defined as no AF, low AF (&lt;5.5 hours on any given day), or high AF burden (\u22655.5 hours in a day), and was first assessed over the initial 30 days following enrollment and then reassessed at 6\u2010month intervals for 2 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 394 patients included, the average age was 70.2 \u00b1 10.9 years, 71% were male, and mean CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2\u2010<\/jats:sub>VASc (congestive heart failure, hypertension, age \u226575 years, diabetes mellitus, prior stroke or TIA, vascular disease, age 65\u201374 years, sex category) score was 3.7 \u00b1 1.6. In the 30\u2010day baseline period, 75.1% of patients had no AF, 11.2% had low AF, and 13.7% had high AF. Over the subsequent 2 years, 40.0% of patients initially classified as no AF or low AF experienced periods with high AF, whereas 59.3% of patients initially classified as high AF experienced \u22656 consecutive months with no AF or low AF. Advanced age was the sole predictor of AF progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significant temporal variability in AF burden exists when measured continuously with an implantable CRMD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22766","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T12:46:40Z","timestamp":1502455600000},"page":"1044-1048","source":"Crossref","is-referenced-by-count":2,"title":["Atrial fibrillation variability on long\u2010term monitoring of implantable cardiac rhythm management devices"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0038-9231","authenticated-orcid":false,"given":"Rachel M.","family":"Kaplan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Disease Management, Medtronic, Inc.  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodi","family":"Koehler","sequence":"additional","affiliation":[{"name":"Cardiac Rhythm Disease Management, Medtronic, Inc.  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taya V.","family":"Glotzer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hackensack University Medical Center  Hackensack New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod S.","family":"Passman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.044"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105575"},{"key":"e_1_2_6_4_1","unstructured":"HealeyJ.Apixaban for the Reduction of Thrombo\u2010Embolism in Patients With Device\u2010Detected Sub\u2010Clinical Atrial Fibrillation (ARTESiA).ClinicalTrials.govIdentifier: NCT01938248.https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01938248. 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