{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:51:41Z","timestamp":1777531901602,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Data are limited on the safety of periprocedural anticoagulation with novel oral anticoagulants (NOACs) in patients undergoing pulmonary vein isolation (PVI) using the second\u2010generation cryoballoon (CB) for the treatment of atrial fibrillation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that the incidence of acute periprocedural complications in patients undergoing PVI do not differ between patients treated with VKA compared to NOACs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 200 consecutive patients (mean age, 64.3 _ 10.6 years; female, n = 83) with symptomatic atrial fibrillation, PVI using the second\u2010generation 28\u2010mm CB was performed. In patients treated with NOACs, the medication was stopped the day of the procedure and continued the evening after the procedure with a reduced dosage. Patients treated with phenprocoumon were continued on uninterrupted phenprocoumon with a target INR of 2 to 3. If INR was &lt;2, bridging with low\u2010molecular\u2010weight heparin was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven of 200 patients (23.5%) were treated with a vitamin K antagonist (VKA) and 55 (27.5%) were treated with apixaban, 67 (33.5%) with rivaroxaban, and 31 (15.5%) with dabigatran. Seven (3.5%) major complications occurred in the overall population. Major bleeding complications did not differ significantly between the 2 groups (P = 0.23). One patient taking VKA had a pericardial tamponade at the end of the procedure; 2 patients treated with apixaban developed a groin hematoma requiring surgical intervention. Transient ischemic attack occurred in 1 patient of the apixaban and rivaroxaban group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Apixaban, rivaroxaban, and dabigatran, compared with uninterrupted VKA, did not show a higher risk for major bleeding or ischemic complications in patients undergoing PVI using the second\u2010generation CB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22782","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T16:52:43Z","timestamp":1503939163000},"page":"1095-1099","source":"Crossref","is-referenced-by-count":7,"title":["Apixaban, rivaroxaban, and dabigatran use in patients undergoing catheter ablation for atrial fibrillation using the second\u2010generation cryoballoon"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-2540","authenticated-orcid":false,"given":"Verena","family":"Tscholl","sequence":"first","affiliation":[{"name":"Department of Cardiology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Khaled\u2010A.","family":"Lsharaf","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Lin","sequence":"additional","affiliation":[{"name":"Cardiology and Electrophysiology, HeartCare  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Bellmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Nagel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Lenz","sequence":"additional","affiliation":[{"name":"Institute for Biometry and Clinical Epidemiology Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Roser","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Rillig","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin  Berlin 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