{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:23:53Z","timestamp":1779229433700,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T00:00:00Z","timestamp":1513382400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Contrast\u2010induced nephropathy (CIN) is a well\u2010recognized complication of coronary angiography that is associated with poor outcomes. Several small randomized controlled trials (RCTs) have recently shown that in patients with chronic kidney disease (CKD), furosemide\u2010induced forced diuresis with matched hydration using the RenalGuard system can prevent its occurrence. However, individual studies have been underpowered and thus cannot show significant differences in major clinical endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Forced diuresis with matched hydration using the RenalGuard system improves clinical outcomes in patients undergoing coronary angiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Scientific databases and websites were searched for relevant RCTs. The pooled risk ratios were calculated using random\u2010effects models. The primary endpoint was CIN, and the secondary endpoints were major adverse clinical events (MACEs) and the need for renal replacement therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 3 trials including 586 patients were analyzed. High\u2010volume forced diuresis with matched hydration using the RenalGuard system decreased risk of CIN by 60% (risk ratio: 0.40, 95% confidence interval: 0.25 to 0.65, <jats:italic>P<\/jats:italic> &lt; 0.001), MACE rate by 59%, and the need for renal replacement therapy by 78%, compared with the standard of care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with CKD undergoing coronary angiography, high\u2010volume forced diuresis with matched hydration using the RenalGuard system significantly reduces the risk of CIN, MACE rate, and the need for renal replacement therapy. Larger RCTs with sufficient power are needed to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22817","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T22:32:06Z","timestamp":1513463526000},"page":"1242-1246","source":"Crossref","is-referenced-by-count":22,"title":["High\u2010volume forced diuresis with matched hydration using the RenalGuard System to prevent contrast\u2010induced nephropathy: A meta\u2010analysis of randomized trials"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9397-272X","authenticated-orcid":false,"given":"Rahman","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Tennessee  Memphis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Tennessee  Memphis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajjad A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine Aga Khan University Medical School  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amina","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Tennessee  Memphis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rehan Khan","sequence":"additional","affiliation":[{"name":"Department of Radiology Veterans Affairs Medical Center  Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed S.","family":"Morsy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of Tennessee  Memphis"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016043.87291.33"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.068"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90090-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22113"},{"key":"e_1_2_6_6_1","unstructured":"BasuA.Contrast\u2010induced nephropathy. 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