{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:16:29Z","timestamp":1790622989576,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>More evidence is needed on the optimal antithrombotic regimen in elderly patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Octogenarian patients (aged \u226580 years) with AF who underwent PCI have worse 12\u2010month clinical outcome, compared with younger patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a post\u2010hoc analysis of data from the prospective, multicenter AFCAS registry, which enrolled consecutive patients with AF who underwent PCI and stenting. Outcome measures included major adverse cardiac\/cerebrovascular events (MACCE; all\u2010cause death, myocardial infarction, repeat revascularization, stent thrombosis, or stroke\/transient ischemic attack) and bleeding events at 12\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 925 AF patients enrolled in AFCAS registry, 195 (21.1%) were \u226580 years. Mean age was 82.9 \u00b1 2.6 years; 41.5% were women; 32.3% had diabetes mellitus. Compared with patients aged &lt;80 years, there were more females among the octogenarians (<jats:italic>P<\/jats:italic> &lt; 0.001). Compared with younger patients, octogenarians smoked and had dyslipidemia less often, and presented more frequently with acute coronary syndrome. The frequency and duration of antithrombotic regimens prescribed at discharge were comparable. At 12\u2010month follow\u2010up, overall MACCE rate was higher in octogenarians compared with younger patients (27.7% vs 20.1%, <jats:italic>P<\/jats:italic> = 0.02). The rate of acute myocardial infarction was higher in octogenarians (9.2% vs 4.9%, <jats:italic>P<\/jats:italic> = 0.02), but the rates of all bleeds and BARC &gt;2 bleeds were similar (<jats:italic>P<\/jats:italic> = 0.13, <jats:italic>P<\/jats:italic> = 0.29, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In real\u2010world patients with AF undergoing PCI, patients aged \u226580 years had higher incidence of MACCE at 12\u2010month follow\u2010up compared with younger patients, although they received comparable antithrombotic treatment. The rates of bleeding events were similar.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22821","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T21:38:58Z","timestamp":1513460338000},"page":"1264-1270","source":"Crossref","is-referenced-by-count":6,"title":["Outcome of octogenarians with atrial fibrillation undergoing percutaneous coronary intervention: insights from the AFCAS registry"],"prefix":"10.1002","volume":"40","author":[{"given":"Heli M.","family":"Lahtela","sequence":"first","affiliation":[{"name":"Emergency Department North\u2010Kymi Hospital  Kouvola Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissa","family":"Bah","sequence":"additional","affiliation":[{"name":"Heart Center Kuopio University Hospital and University of Kuopio  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Kiviniemi","sequence":"additional","affiliation":[{"name":"Heart Center Turku University Hospital and University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wail","family":"Nammas","sequence":"additional","affiliation":[{"name":"Heart Center Satakunta Central Hospital  Pori Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schlitt","sequence":"additional","affiliation":[{"name":"Medical Faculty, Martin Luther University Halle, Germany and Department of Cardiology, Paracelsus Harz\u2010Clinic  Bad Suderode Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rubboli","sequence":"additional","affiliation":[{"name":"Division of Cardiology Laboratory of Interventional Cardiology, Ospedale Maggiore  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4099-1334","authenticated-orcid":false,"given":"Pasi P.","family":"Karjalainen","sequence":"additional","affiliation":[{"name":"Heart Center Satakunta Central Hospital  Pori Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Proietti","sequence":"additional","affiliation":[{"name":"University of Birmingham Institute of Cardiovascular Sciences City Hospital  Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha E.K.","family":"Hartikainen","sequence":"additional","affiliation":[{"name":"Heart Center Kuopio University Hospital and University of Kuopio  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[{"name":"University of Birmingham Institute of Cardiovascular Sciences City Hospital  Birmingham United Kingdom"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0193-568X","authenticated-orcid":false,"given":"K.E. Juhani","family":"Airaksinen","sequence":"additional","affiliation":[{"name":"Heart Center Turku University Hospital and University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"73","article-title":"Evolving trends in percutaneous coronary intervention","volume":"18","author":"Rajani R","year":"2011","journal-title":"Br J Cardiol."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2006.00192.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I8A153"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.6.708"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi825"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890802089786"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22254"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62177-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611594"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708454"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs121"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.07.031"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20768"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14017431.2016.1233352"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-016-0383-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003027"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24591"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T15:33:08Z","timestamp":1695828788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/clc.22821"],"URL":"https:\/\/doi.org\/10.1002\/clc.22821","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}