{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:37:27Z","timestamp":1764700647550,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology","award":["2012R1A4A1029061 and 2014R1A1A2056104"],"award-info":[{"award-number":["2012R1A4A1029061 and 2014R1A1A2056104"]}]},{"name":"The Bio & Medical Technology Development Program of the NRF funded by the Korean government, MSIP","award":["2015M3A9B6029138"],"award-info":[{"award-number":["2015M3A9B6029138"]}]},{"name":"The National Research Council of Science & Technology grant by the Korean government, MSIP","award":["CAP-12-2-KBSI"],"award-info":[{"award-number":["CAP-12-2-KBSI"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Data on treatment results of lipid\u2010lowering therapy (LLT) in familial hypercholesterolemia (FH) are limited, particularly in Asian patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We sought to evaluate the target achievement rate and associated variables in Korean patients with FH after maximal statin\u2010based LLT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 146 patients with heterozygous FH, and 90 patients were finally analyzed. Patients were initially prescribed rosuvastatin 10 mg or atorvastatin 20 mg, and the regimen was adjusted to achieve the low\u2010density lipoprotein cholesterol (LDL\u2010C) target of 100 mg\/dL. The primary evaluation point was the achievement rate of the LDL\u2010C targets at 12 months: LDL\u2010C &lt; 100 mg\/dL and \u226550% LDL\u2010C reduction. The associations between clinical variables and target achievement were also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 12 months, 58% of patients were receiving high\u2010intensity regimens, whereas 46% were receiving combination therapy. The mean pre\u2010 and post\u2010treatment LDL\u2010C levels were 229 and 118 mg\/dL, respectively. Twenty\u2010eight percent of patients achieved LDL\u2010C &lt; 100 mg\/dL, and 47% achieved \u226550% LDL\u2010C reduction. Pretreatment LDL\u2010C and high\u2010intensity regimens indicated a negative tendency toward the attainment of LDL\u2010C &lt; 100 mg\/dL. Conversely, pretreatment LDL\u2010C and diabetes mellitus were positively associated with a higher rate of \u226550% LDL\u2010C reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The target achievement of LDL\u2010C &lt; 100 mg\/dL was low, and 50% LDL\u2010C reduction was moderately achieved in Korean patients with FH receiving maximal statin\u2010based LLT. Pretreatment LDL\u2010C levels and diabetes mellitus were associated with target achievement. Our results provide rare and informative data on FH treatment in Asian patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22826","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T10:41:39Z","timestamp":1513420899000},"page":"1291-1296","source":"Crossref","is-referenced-by-count":10,"title":["Target achievement with maximal statin\u2010based lipid\u2010lowering therapy in Korean patients with familial hypercholesterolemia: A study supported by the Korean Society of Lipid and Atherosclerosis"],"prefix":"10.1002","volume":"40","author":[{"given":"Jaewon","family":"Oh","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doo Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Internal Medicine, Haeundae Paik Hospital Inje University College of Medicine  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moo\u2010Yong","family":"Rhee","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Dongguk University Ilsan Hospital  Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung\u2010Kwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngkeun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Heart Center of Chonnam National University Hospital  Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Ryul","family":"Cho","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Internal Medicine, Kangwon National University Hospital Kangwon National University College of Medicine  Chunchon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Taek","family":"Woo","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Department of Internal Medicine Kyunghee University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Ho","family":"Hur","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Internal Medicine Keimyung University Dongsan Medical Center  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Ok","family":"Jeong","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Internal Medicine, School of Medicine, Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangsoo","family":"Jang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Cardiovascular Research Institute Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-3745","authenticated-orcid":false,"given":"Sang\u2010Hak","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Cardiovascular Research Institute Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91755-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050461"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2423"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.4143"},{"key":"e_1_2_7_6_1","first-page":"252","article-title":"Statins in familial hypercholesterolemia","volume":"68","author":"Besseling J","year":"2016","journal-title":"consequences for coronary artery disease and all\u2010cause mortality. 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