{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:26:32Z","timestamp":1782480392152,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T00:00:00Z","timestamp":1513382400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Coronary artery disease (CAD) is common in patients undergoing transcatheter aortic valve replacement (TAVR). However, the impact of CAD distribution before TAVR on short\u2010 and long\u2010term prognosis remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that the long\u2010term clinical impact differs according to CAD distribution in patients undergoing TAVR using the FRench Aortic National CoreValve and Edwards (FRANCE\u20102) registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FRANCE\u20102 is a national French registry including all consecutive TAVR performed between 2010 and 2012 in 34 centers. Three\u2010year mortality was assessed in relation to CAD status. CAD was defined as at least 1 coronary stenosis &gt;50%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4201 patients were enrolled in the registry. For the present analysis, we excluded patients with a history of coronary artery bypass. CAD was reported in 1252 patients (30%). Half of the patients presented with coronary multivessel disease. CAD extent was associated with an increase in cardiovascular risk profile and in logistic EuroSCORE (European System for Cardiac Operative Risk Evaluation) (from 19.3% \u00b1 12.8% to 21.9% \u00b1 13.5%, <jats:italic>P<\/jats:italic> &lt; 0.001). Mortality at 30 days and 3 years was 9% and 44%, respectively, in the overall population. In multivariate analyses, neither the presence nor the extent of CAD was associated with mortality at 3 years (presence of CAD, hazard ratio [HR]: 0.90; 95% confidence interval [CI]: 0.78\u20101.07). A significant lesion of the left anterior descending (LAD) was associated with higher 3\u2010year mortality (HR: 1.42; 95% CI: 1.10\u20101.87).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CAD is not associated with decreased short\u2010 and long\u2010term survival in patients undergoing TAVR. The potential deleterious effect of LAD disease on long\u2010term survival and the need for revascularization before or at the time of TAVR should be validated in a randomized control trial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22830","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T22:36:21Z","timestamp":1513463781000},"page":"1316-1322","source":"Crossref","is-referenced-by-count":34,"title":["Impact of coronary artery disease in patients undergoing transcatheter aortic valve replacement: Insights from the FRANCE\u20102 registry"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0533-9682","authenticated-orcid":false,"given":"Etienne","family":"Puymirat","sequence":"first","affiliation":[{"name":"Department of Cardiology, European Hospital of Georges Pompidou Public Assistance Hospitals of Paris, Paris Descartes University  Paris 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