{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:35:00Z","timestamp":1771331700505,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T00:00:00Z","timestamp":1513382400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangdong Provincial Science and Technology Program","award":["2013B021800140"],"award-info":[{"award-number":["2013B021800140"]}]},{"name":"Guangzhou Science and Technology Project","award":["201300000146"],"award-info":[{"award-number":["201300000146"]}]},{"name":"Southern Medical University Clinical Research Project","award":["LC2016ZD002"],"award-info":[{"award-number":["LC2016ZD002"]}]},{"name":"President's Fund of Nanfang Hospital","award":["2016B015"],"award-info":[{"award-number":["2016B015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pharmacological treatment during ablation of persistent atrial fibrillation (AF) is common, but utility of irrigated catheter application of amiodarone during ablation of persistent AF remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Irrigated catheter application of amiodarone improves quality of ablation and long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 90 persistent AF patients who underwent catheter ablation. Patients were randomized to the amiodarone group (n = 45) or control group (n = 45). All patients underwent stepwise ablation beginning with isolation of the pulmonary veins. Next, we performed ablation of linear lesions and focal triggers until sinus rhythm (SR) was achieved. The primary endpoint was documented atrial arrhythmia during follow\u2010up. The secondary endpoint was cardioversion to SR during ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All pulmonary veins were successfully isolated. Conversion of AF to SR occurred more frequently in the amiodarone group than in the control group (33 vs 23 [73.3% vs 51.1%]; <jats:italic>P<\/jats:italic> = 0.03). The amiodarone group had lower procedure, radiofrequency, and fluoroscopy times than the control group (167.4 \u00b1 22.5 min vs 186.7 \u00b1 25.3 min; 78.3 \u00b1 14.2 min vs 90.4 \u00b1 15.5 min; and 6.5 \u00b1 1.9 min vs 8.6 \u00b1 2.4 min, respectively; <jats:italic>P<\/jats:italic> &lt; 0.05). More importantly, the atrial arrhythmia recurrence\u2010free survival rates were 80% in the amiodarone group and 60% in the control group during the 14.7 \u00b1 7.5\u2010month follow\u2010up (<jats:italic>P<\/jats:italic> = 0.043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Irrigated catheter application of amiodarone during ablation for persistent AF resulted in higher cardioversion rates and lower procedure times and significantly reduced rates of atrial arrhythmia recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22835","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T22:42:40Z","timestamp":1513464160000},"page":"1333-1338","source":"Crossref","is-referenced-by-count":5,"title":["Clinical efficacy of irrigated catheter application of amiodarone during ablation of persistent atrial fibrillation"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-4602","authenticated-orcid":false,"given":"Xingfu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuli","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First People's Hospital of Shunde  Foshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-2797","authenticated-orcid":false,"given":"Hongxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Roche Pharmaceuticals Ltd.  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenrong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Shee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingli","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.088"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00956.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408288"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07748-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut399"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq041"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e3283413925"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01959.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.11.016"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-008-9252-z"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.04.005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-015-0771-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.06.061"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000055316.35552.74"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.839639"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.01.003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu354"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12682"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu382"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.22835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.22835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T15:33:02Z","timestamp":1695828782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.22835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/clc.22835"],"URL":"https:\/\/doi.org\/10.1002\/clc.22835","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}