{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:53:08Z","timestamp":1740145988886,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T00:00:00Z","timestamp":1514419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>For decades, fasting for 8 to 12\u2009hours has been recommended for measurement of lipid profiles. The effect of fasting on low\u2010density lipoprotein cholesterol (LDL\u2010C) and triglycerides (TG) has been described in healthy cohorts and those with stable disease states. Recently, guidelines suggested that fasting may not be necessary due to its small effect on lipid measures. Little is known, however, regarding whether the impact of fasting is altered in the setting of an acute coronary syndrome (ACS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that the post\u2010ACS period would minimally effect the impact of fasting status on lipid measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the association of fasting on lipid and other biomarkers at the randomization visit, which occurred at a median of 7\u2009days after the onset of an ACS, as well as during follow\u2010up, in a cohort of 4177 subjects from the Pravastatin or Atorvastatin Evaluation and Infection Therapy\u2013Thrombolysis In Myocardial Infarction 22 (PROVE IT\u2013TIMI 22) trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fasting samples were independently associated with a higher LDL\u2010C of 4.1\u2009mg\/dL and apolipoprotein\u2010B 100 of 2.6\u2009mg\/dL as well as a lower TG of 21.0\u2009mg\/dL and high\u2010sensitivity C\u2010reactive protein of 0.48\u2009mg\/dL. The relative difference was 3.8% for LDL\u2010C and \u221211.3% for TG. Fasting did not change total cholesterol, high\u2010density lipoprotein cholesterol, apolipoprotein A\u2010I, lipoprotein(a), or apolipoprotein C\u2010III.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although fasting does impact lipid measurements, the effect on LDL\u2010C is small (about 4\u2009mg\/dL), both early after ACS and during follow\u2010up. These data provide support for recent guidelines that no longer advocate for fasting lipid samples, including in the setting of ACS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22851","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T13:53:50Z","timestamp":1514469230000},"page":"68-73","source":"Crossref","is-referenced-by-count":4,"title":["The effect of fasting status on lipids, lipoproteins, and inflammatory biomarkers assessed after hospitalization for an acute coronary syndrome: Insights from PROVE IT\u2013TIMI 22"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2383-895X","authenticated-orcid":false,"given":"Dylan L.","family":"Steen","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Cincinnati Medical Center  Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amarachi A.","family":"Umez\u2010Eronini","sequence":"additional","affiliation":[{"name":"Department of Cardiology Brigham and Women's Hospital  Boston Massachusetts"},{"name":"Department of Biostatistics Prometrika, LLC  Cambridge Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naseer","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Cincinnati Medical Center  Cincinnati Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Cardiology Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040583"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.038"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.181735"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.612630"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.042"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02934762"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2012.3708"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.804146"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80184-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2000.03509.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0022-2275(20)38520-5","article-title":"et. 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