{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:47:46Z","timestamp":1780940866695,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangdong Provincial Science and Technology Program","award":["2013B021800140"],"award-info":[{"award-number":["2013B021800140"]}]},{"name":"Guangzhou Science and Technology Project","award":["201300000146"],"award-info":[{"award-number":["201300000146"]}]},{"name":"Southern Medical University Clinical Research Project","award":["LC2016ZD002"],"award-info":[{"award-number":["LC2016ZD002"]}]},{"name":"President's Fund of Nanfang Hospital","award":["2016B015"],"award-info":[{"award-number":["2016B015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to explore electrophysiological characteristics of premature atrial contractions (PACs) originating from pulmonary veins (PVs) and non\u2010PVs and to evaluate the effectiveness and safety of catheter ablation for PACs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Symptomatic PACs originated from different positions and whether could be ablated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Symptomatic, frequent, and drug\u2010refractory PAC patients were enrolled in this study. All patients underwent electrophysiological study and catheter ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 81 patients were enrolled: 45 patients with PACs originating from PVs (group A), 24 patients with PACs originating from non\u2010PVs (group B), and 12 patients with PACs arising from both PVs and non\u2010PVs (group C). Twenty (44.4%) patients in group A, 6 (50.0%) patients in group C, and 3 (12.5%) patients in group B presented paroxysmal atrial fibrillation (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). PV isolation was performed in groups A and C. Focal ablation or superior vena cava isolation was performed in groups B and C, depending on patient condition. PACs were abolished in all patients except one patient in group B. During a median follow\u2010up period of 21.3\u2009\u00b1\u200914.3\u2009months, 40 (88.9%) patients in group A, 10 (83.3%) patients in group C, and 21 (87.5%) patients in group B were free of recurrence after initial ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Frequent PACs originating from PVs were associated with increased incidence of atrial fibrillation compared with PACs originating from non\u2010PVs. Catheter ablation yields a satisfactory success rate and could be a good choice for eliminating symptomatic, frequent, and drug\u2010refractory PACs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22853","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T12:48:44Z","timestamp":1516884524000},"page":"74-80","source":"Crossref","is-referenced-by-count":8,"title":["Electrophysiological characteristics and catheter ablation of symptomatic focal premature atrial contractions originating from pulmonary veins and non\u2010pulmonary veins"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-4602","authenticated-orcid":false,"given":"Xingfu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Huadu District People's Hospital Southern Medical University  Guangzhou Guangdong province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-2797","authenticated-orcid":false,"given":"Hongxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Roche Pharmaceuticals Ltd.  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