{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:22Z","timestamp":1786977502863,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Johnsie and Aubary Montgomery Institute of Medical Education and Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"\n Background<\/jats:title>\n Cardiovascular disease (CVD) is a major economic burden in the United States. CVD risk factors, particularly hypertension and hypercholesterolemia, are typically treated with drug therapy. Five\u2010year efficacy of such drugs to prevent CVD is estimated to be 5%. Plant\u2010based diets have emerged as effective mitigators of these risk factors.<\/jats:p>\n <\/jats:sec>\n \n Hypothesis<\/jats:title>\n The implementation of a defined, plant\u2010based diet for 4\u2009weeks in an outpatient clinical setting may mitigate CVD risk factors and reduce patient drug burden.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Participants consumed a plant\u2010based diet consisting of foods prepared in a defined method in accordance with a food\u2010classification system. Participants consumed raw fruits, vegetables, seeds, and avocado. All animal products were excluded from the diet. Participant anthropometric and hemodynamic data were obtained weekly for 4\u2009weeks. Laboratory biomarkers were collected at baseline and at 4\u2009weeks. Medication needs were assessed weekly. Data were analyzed using paired\u2010samples\n t<\/jats:italic>\n tests and 1\u2010way repeated\u2010measures ANOVA.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Significant reductions were observed for systolic (\u221216.6\u2009mmHg) and diastolic (\u22129.1\u2009mmHg) blood pressure (\n P<\/jats:italic>\n \u2009<\u20090.0005), serum lipids (\n P<\/jats:italic>\n \u2009\u2264\u20090.008), and total medication usage (\n P<\/jats:italic>\n \u2009<\u20090.0005). Other CVD risk factors, including weight (\n P<\/jats:italic>\n \u2009<\u20090.0005), waist circumference (\n P<\/jats:italic>\n \u2009<\u20090.0005), heart rate (\n P<\/jats:italic>\n \u2009=\u20090.018), insulin (\n P<\/jats:italic>\n \u2009<\u20090.0005), glycated hemoglobin (\n P<\/jats:italic>\n \u2009=\u20090.002), and high\u2010sensitivity C\u2010reactive protein (\n P<\/jats:italic>\n \u2009=\u20090.001) were also reduced.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n A defined, plant\u2010based diet can be used as an effective therapeutic strategy in the clinical setting to mitigate cardiovascular risk factors and reduce patient drug burden.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/clc.22863","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T14:04:21Z","timestamp":1521986661000},"page":"307-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["A defined, 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