{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:56:46Z","timestamp":1791647806539,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation is one of the most common abnormal heart rhythms. Neutrophil\u2010lymphocyte ratio (NLR) has emerged as a potential marker for the level of inflammation in cardiac disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>NLR might be associated with thrombosis and bleeding risk scores and might predict cardioembolic risk in nonvalvular atrial fibrillation (NVAF) patients within the therapeutic international normalized ratio (INR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 272 patients taking warfarin for NVAF and classified them into 2 groups: Group A consisted of patients (n\u2009=\u2009132) whose time in therapeutic range (TTR) was \u226565%, and Group B comprised patients (n\u2009=\u2009139) whose TTR was &lt;65%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NLR values were higher in group B than in group A (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Patients classified as high risk according to CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score had significantly higher NLR levels (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) than those classified as low and intermediate risk. Furthermore, NLR levels were significantly correlated with CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc and HAS\u2010BLED scores (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, respectively). NLR predicted patients within therapeutic INR range (TTR \u226565%) with sensitivity of 81% and specificity of 71% in a receiver operator characteristic curve analysis, using a cutoff value of 2.17. Area under the curve for NLR was 0.81 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this is the first study showing correlation of NLR with both CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc and HAS\u2010BLED risk scores. NLR might represent a useful marker to identify patients with high risks of stroke and bleeding and may have predictive value in identifying patients within the therapeutic INR range.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22869","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T06:47:01Z","timestamp":1521787621000},"page":"339-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Use of neutrophil\u2010lymphocyte ratio for risk stratification and relationship with time in therapeutic range in patients with nonvalvular atrial fibrillation: A pilot study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-5874","authenticated-orcid":false,"given":"Kahraman","family":"Cosansu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Education and Research Hospital Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Bulent","family":"Vatan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Education and Research Hospital Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Gunduz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Education and Research Hospital Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramazan","family":"Akdemir","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Education and Research Hospital Sakarya University  Sakarya 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