{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:30:07Z","timestamp":1776472207205,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Trastuzumab (TZ) therapy requires careful monitoring of left ventricular (LV) ejection fraction (LVEF) because it can be potentially cardiotoxic. However, LVEF is an imperfect parameter and there is a need to find other variables to predict cardiac dysfunction early. Left atrium (LA) enlargement has proven to be a powerful predictor of adverse outcomes in several disease entities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Baseline LA volume enlargement might predict TZ\u2010related LV dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HER2\u2010positive breast cancer patients receiving TZ and undergoing transthoracic echocardiography at baseline and at follow\u2010up every 3\u2009months were retrospectively recruited. One\u2010hundred sixty\u2010two patients formed the study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline LAVI was dilated in 14 patients (8.6%). Mean follow\u2010up was 14\u2009\u00b1\u20094\u2009months. Cardiotoxicity occurred in 24 patients (14.8%). LAVI was an independent predictor of TZ\u2010induced LV dysfunction in a clinical model, after adjustment for age and hypertension (odds ratio per 5\u2010mL\/m<jats:sup>2<\/jats:sup> LAVI increase: 1.34, 95% confidence interval: 1.03\u20101.82, <jats:italic>P<\/jats:italic>\u2009=\u20090.03); and in a hemodynamic model, including ventricular sizes and systolic blood pressure level (odds ratio per 5\u2010mL\/m<jats:sup>2<\/jats:sup> LAVI increase: 1.34, 95% confidence interval: 1.01\u20101.81, <jats:italic>P<\/jats:italic>\u2009=\u20090.04). The predicted probability of developing cardiotoxicity increased progressively, in parallel with LAVI values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Baseline LA dilatation emerges as a condition associated with the development of cardiotoxicity in HER2\u2010positive breast cancer patients treated with TZ.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22872","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T06:58:21Z","timestamp":1521788301000},"page":"349-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Left atrial volume in patients with HER2\u2010positive breast cancer: One step further to predict trastuzumab\u2010related cardiotoxicity"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1026-3376","authenticated-orcid":false,"given":"Corinna","family":"Bergamini","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Dolci","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Torelli","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Ghiselli","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Trevisani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Vinco","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Truong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"La Russa","sequence":"additional","affiliation":[{"name":"Division of Oncology Azienda Ospedaliera Universitaria Integrata di Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Golia","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Molino","sequence":"additional","affiliation":[{"name":"Division of Oncology Azienda Ospedaliera Universitaria Integrata di Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Benfari","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio Luciano","family":"Ribichini","sequence":"additional","affiliation":[{"name":"Division of Cardiology, 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