{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:48:32Z","timestamp":1785498512350,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Late gadolinium enhancement (LGE) assessed with cardiovascular magnetic resonance (CMR) correlates with ventricular arrhythmias and survival in patients with structural heart disease. Whether some LGE characteristics may specifically improve prediction of arrhythmic outcomes is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We sought to evaluate scar characteristics assessed with CMR to predict implantable cardioverter\u2010defibrillator (ICD) interventions in dilated cardiomyopathy of different etiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>96 consecutive patients evaluated with CMR received an ICD. Biventricular volumes, ejection fraction, and myocardial LGE were evaluated. LGE was defined as \u201ccomplex\u201d (Cx\u2010LGE) in presence of \u22651 of the following: ischemic pattern, involving \u22652 different coronary territories; epicardial pattern; global endocardial pattern; and presence of \u22652 different patterns. The primary endpoint was occurrence of any appropriate ICD intervention. A composite secondary endpoint of cardiovascular death, cardiac transplantation, or ventricular assist device implantation was also considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 75 months, 30 and 25 patients reached the primary and secondary endpoints, respectively. Cx\u2010LGE was correlated with a worse primary endpoint survival (log\u2010rank <jats:italic>P<\/jats:italic> &lt; 0.001). Cx\u2010LGE and right ventricular end\u2010diastolic volume were independently associated with the primary endpoint (HR: 3.22, 95% CI: 1.56\u20136.65, <jats:italic>P<\/jats:italic> = 0.002; and HR: 1.06, 95% CI: 1.00\u20131.12, <jats:italic>P<\/jats:italic> = 0.045, respectively), but not with the secondary endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cx\u2010LGE identified at CMR imaging seems promising as an independent and specific prognostic factor of ventricular arrhythmias requiring ICD therapy in dilated cardiomyopathy of different etiologies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22911","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T08:58:17Z","timestamp":1523955497000},"page":"494-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Complexity of scar and ventricular arrhythmias in dilated cardiomyopathy of any etiology: Long\u2010term data from the SCARFEAR (Cardiovascular Magnetic Resonance Predictors of Appropriate Implantable Cardioverter\u2010Defibrillator Therapy Delivery) Registry"],"prefix":"10.1002","volume":"41","author":[{"given":"Stefano","family":"Pedretti","sequence":"first","affiliation":[{"name":"Electrophysiology Unit, \u201cA De Gasperis\u201d Cardio Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"},{"name":"Cardiovascular Magnetic Resonance Service, \u201cA De Gasperis\u201d Cardio Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Vargiu","sequence":"additional","affiliation":[{"name":"Electrophysiology Unit, \u201cA De Gasperis\u201d Cardio Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Baroni","sequence":"additional","affiliation":[{"name":"Electrophysiology Unit, \u201cA De Gasperis\u201d Cardio Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santo","family":"Dellegrottaglie","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Service, \u201cA De Gasperis\u201d Cardio Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Lanzarin","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Service, \u201cA De Gasperis\u201d Cardio Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Roghi","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Service, \u201cA De Gasperis\u201d Cardio Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Milazzo","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Service, \u201cA De Gasperis\u201d Cardio Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Quattrocchi","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Service, \u201cA De Gasperis\u201d Cardio Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Lunati","sequence":"additional","affiliation":[{"name":"Electrophysiology Unit, \u201cA De Gasperis\u201d Cardio Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Pedrotti","sequence":"additional","affiliation":[{"name":"Cardiovascular Magnetic Resonance Service, \u201cA De Gasperis\u201d Cardio Center ASST Grande Ospedale Metropolitano Niguarda  Milan 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