{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:28:53Z","timestamp":1761060533277,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009187","name":"Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009187","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Left ventricular ejection fraction (LVEF) has shown to predict outcomes in patients with heart failure (HF). Left ventricular recovery (LVR) has shown to improve prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis.<\/jats:title><jats:p>Guideline\u2010directed medical therapy will predict LVR in patients with HF and reduced LVEF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 244 patients with newly diagnosed HF and an LVEF \u226435%. LVR was defined as an increase in LVEF \u226540%. Patients who experienced LVR were compared with those who had persistent left ventricular dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Population characteristics included ischemic etiology, 38.1%; baseline LVEF, 23%\u2009\u00b16%; and mean baseline heart rate (HR), 75\u2009\u00b113\u2009bpm. Guideline\u2010directed medical therapy was achieved as follows: angiotensin\u2010converting enzyme inhibitors, 74.3%; \u03b2\u2010blockers (BB), 95.4%; target dosing of angiotensin\u2010converting enzyme inhibitors, 33.7%; target dosing of BB, 40.2%. LVR occurred in 154\/244 patients (63.1%). By multivariable analysis, baseline HR \u226470\u2009bpm was the only independent predictor of LVR (odds ratio: 3.39, 95% confidence interval: 1.5\u20137.5, <jats:italic>P<\/jats:italic>\u2009=\u20090.003). Target dosing of BB therapy was predictive of LVR only in the univariate analysis (odds ratio: 1.9, 95% confidence interval: 1.1\u20133.4, <jats:italic>P<\/jats:italic>\u2009=\u20090.03). Furthermore, the composite endpoint of HF hospitalization or mortality occurred less frequently in those who did vs those who did not achieve target BB doses (5.4% vs 16.7%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel findings of our analysis reveal that the only predictor of LVR in this study was a low baseline HR. Early modulation of HR in newly diagnosed HF patients may increase the rates of LVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22937","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T06:45:03Z","timestamp":1520405103000},"page":"752-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Importance of baseline heart rate as a predictor of cardiac functional recovery in newly diagnosed heart failure with reduced ejection fraction"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8384-6965","authenticated-orcid":false,"given":"Ali","family":"Valika","sequence":"first","affiliation":[{"name":"Department of Cardiology Advocate Heart Institute  Oak Brook Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Paprockas","sequence":"additional","affiliation":[{"name":"Advocate Research Institute Advocate Health Care  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