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Cox regression examined the association of forced vital capacity (FVC) and 1\u2010second forced expiratory volume (FEV<jats:sub>1<\/jats:sub>; percent of predicted values) with incident coronary heart disease and CVD events over 12.9\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DM was present in 537 (13.1%) and MetS in 1277 (31.0%) participants. Comparing fourth vs first quartiles for FVC, risk of CVD events was 16% (HR: 0.84, 95% CI: 0.59\u20131.18), 23% (HR: 0.77, 95% CI: 0.60\u20130.99), and 30% (HR: 0.70, 95% CI: 0.58\u20130.84) lower in DM, MetS, and neither disease groups, respectively. For FEV<jats:sub>1<\/jats:sub>, CVD risk was lower by 2% (HR: 0.98, 95% CI: 0.70\u20131.37), 26% (HR: 0.74, 95% CI: 0.59\u20130.93), and 31% (HR: 0.69, 95% CI: 0.57\u20130.82) in DM. Findings were strongest for predicting congestive heart failure (CHF) in all disease groups. C\u2010statistics increased significantly with addition of FEV<jats:sub>1<\/jats:sub> or FVC over risk factors for CVD and CHF among those with neither MetS nor DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FEV<jats:sub>1<\/jats:sub> and FVC are inversely related to CVD in older adults with and without MetS, but not DM (except for CHF); however, their value in incremental risk prediction beyond standard risk factors is limited mainly to metabolically healthier persons.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22985","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T06:05:22Z","timestamp":1527228322000},"page":"959-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of lung\u2010function measures on cardiovascular disease events in older adults with metabolic syndrome and diabetes"],"prefix":"10.1002","volume":"41","author":[{"given":"Hwa Mu","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine University of California Irvine School of Medicine  Irvine California"},{"name":"Heart Disease Prevention Program, Division of Cardiology University of California Irvine School of Medicine  Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanglu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Heart Disease Prevention Program, Division of Cardiology University of California Irvine School of Medicine  Irvine California"},{"name":"University of California Los Angeles School of Public Health  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Liu","sequence":"additional","affiliation":[{"name":"Heart Disease Prevention Program, Division of Cardiology University of California Irvine School of Medicine  Irvine California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Yanez","sequence":"additional","affiliation":[{"name":"Division of Biostatistics University of Washington School of Public Health  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Carnethon","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine\u2013Epidemiology Northwestern University School of Medicine  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Graham Barr","sequence":"additional","affiliation":[{"name":"Division of Medicine and Epidemiology Columbia University  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-7324","authenticated-orcid":false,"given":"Nathan D.","family":"Wong","sequence":"additional","affiliation":[{"name":"Heart Disease Prevention Program, Division of Cardiology 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