{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:14:55Z","timestamp":1791814495946,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T00:00:00Z","timestamp":1534464000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R34HL121402"],"award-info":[{"award-number":["1R34HL121402"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R34HL121402\u201301"],"award-info":[{"award-number":["1R34HL121402\u201301"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>There is clear association between the intensity of the acute inflammatory response during acute myocardial infarction (AMI) and adverse prognosis after AMI. Interleukin\u20101 (IL\u20101) is a pro\u2010inflammatory cytokine released during AMI and involved in adverse remodeling and heart failure (HF). We describe a study to evaluate the safety and efficacy of IL\u20101 blockade using an IL\u20101 receptor antagonist (anakinra) during the acute phase of ST\u2010segment elevation myocardial infarction (STEMI). The Virginia Commonwealth University\u2013Anakinra Remodeling Trial\u20103 (VCU\u2010ART3; <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.ClinicalTrials.gov<\/jats:ext-link> NCT01950299) is a phase 2, multicenter, double\u2010blinded, randomized, placebo\u2010controlled clinical trial comparing anakinra 100 mg once or twice daily vs matching placebo (1:1:1) for 14 days in 99 patients with STEMI. Patients who present to the hospital with STEMI within 12 hours of symptom onset will be eligible for enrollment. Patients will be excluded for a history of HF (functional class III\u2013IV), severe valvular disease, severe kidney disease (stage 4\u20135), active infection, recent use of immunosuppressive drugs, active malignancy, or chronic autoimmune\/auto\u2010inflammatory diseases. We will measure the difference in the area under the curve for C\u2010reactive protein between admission and day 14, separately comparing each of the anakinra groups with the placebo group. The <jats:italic>P<\/jats:italic> value will be considered significant if &lt;0.025 to adjust for multiple comparisons. Patients will also be followed for up to 12 months from enrollment to evaluate cardiac remodeling (echocardiography), cardiac function (echocardiography), and major adverse cardiovascular outcomes (cardiovascular death, MI, revascularization, and new onset of HF).<\/jats:p>","DOI":"10.1002\/clc.22988","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T09:03:44Z","timestamp":1532336624000},"page":"1004-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Rationale and design of the Virginia Commonwealth University\u2013Anakinra Remodeling Trial\u20103 (VCU\u2010ART3): A randomized, placebo\u2010controlled, double\u2010blinded, multicenter study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0688-4487","authenticated-orcid":false,"given":"Benjamin W.","family":"Van Tassell","sequence":"first","affiliation":[{"name":"VCU Pauley Heart Center 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