{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:56:01Z","timestamp":1784030161583,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with atrial fibrillation, ablation decreases left atrial (LA) compliance, which may lead to left ventricular (LV) diastolic dysfunction. We aimed to examine serial changes in LV diastolic function after 2 ablation procedures and their related factors in patients with paroxysmal atrial fibrillation (PAF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>LV diastolic function is different after 2 ablation procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 132 patients with PAF (76 males, mean age 67 years; cryoballoon [CB] ablation\/radiofrequency [RF] ablation 60\/72) who underwent a single ablation procedure. The transthoracic echocardiographic parameters were obtained before, 3 days after, and 6 months after ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The afterload\u2010related index of LV diastolic function, Ed\/Ea = E\/e' \/ (0.9 \u00d7 systolic blood pressure), increased significantly at 3 days after ablation, especially after CB ablation (<jats:italic>P<\/jats:italic> &lt;0.05), although no differences were observed in age, sex, LA size, LV size, and E\/e' before ablation between CB ablation and RF ablation. Creatine kinase release after ablation was significantly higher in CB ablation than in RF ablation (<jats:italic>P<\/jats:italic> &lt;0.001). The increment of Ed\/Ea after CB ablation was positively correlated with LV ejection fraction (LVEF) before ablation (<jats:italic>r<\/jats:italic> =0.416; <jats:italic>P<\/jats:italic> &lt;0.05). The elderly (age \u2265 75 years), females, and patients with hypertension were more likely to show impaired LV diastolic function transiently after 3 days of ablation, but the diastolic index was restored to baseline level after 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The increased Ed\/Ea after CB ablation represented transient manifestation of underlying LV diastolic dysfunction in PAF patients with preserved LVEF with older age, female sex, and a history of hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22990","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T06:16:21Z","timestamp":1528179381000},"page":"978-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Transient manifestation of left ventricular diastolic dysfunction following ablation in patients with paroxysmal atrial fibrillation"],"prefix":"10.1002","volume":"41","author":[{"given":"Tomoko","family":"Minamisaka","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Yao Municipal Hospital, Yao  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Yao Municipal Hospital, Yao  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinori","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Yao Municipal Hospital, Yao  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniyasu","family":"Ikeoka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Yao Municipal Hospital, Yao  Osaka 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