{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:26:50Z","timestamp":1774625210803,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T00:00:00Z","timestamp":1534464000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity can lead to increased oxidative stress which is one of the proposed mechanisms in the etiopathogenesis of takotsubo cardiomyopathy (TCM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The presence of obesity adversely impacts clinical outcomes in TCM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We queried the Nationwide Inpatient Sample database (2010\u20102014) to identify adult patients admitted with a principal diagnosis of TCM with and without obesity. We compared the categorical and continuous variables by Pearson \u03c7<jats:sup>2<\/jats:sup> and Student <jats:italic>t<\/jats:italic> test, respectively, in propensity\u2010score matched cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort comprised 612 obese TCM (weighted n = 3034) and 5696 nonobese TCM (weighted n = 28 186) patients. Obese TCM patients were more often younger and private\u2010insurance enrollees. Cardiac complications including acute myocardial infarction (9.0% vs 7.4%; <jats:italic>P<\/jats:italic> = 0.04), cardiac arrest (2.3% vs. 0.4%; <jats:italic>P<\/jats:italic> &lt; 0.001), cardiogenic shock (4.3% vs. 3.2%; <jats:italic>P<\/jats:italic> = 0.03), congestive heart failure (5.0% vs. 3.8%; <jats:italic>P<\/jats:italic> = 0.02), respiratory failure (12.9% vs. 11.0%; <jats:italic>P<\/jats:italic> = 0.021) and use of mechanical hemodynamic support (Impella; 0.2% vs. 0.0%, <jats:italic>P<\/jats:italic> = 0.02) were significantly higher among obese TCM patients. There were no significant differences between the 2 groups in all\u2010cause mortality (1.0% vs. 0.8%; <jats:italic>P<\/jats:italic> = 0.35), arrhythmia (24.5% vs. 22.7%, <jats:italic>P<\/jats:italic> = 0.123), length of stay (3.7 \u00b13.5 vs. 3.7 \u00b13.6 days; <jats:italic>P<\/jats:italic> = 0.68), and total hospital charges ($40 780.16 vs. $42 575.14; <jats:italic>P<\/jats:italic> = 0.08).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obese TCM patients were more susceptible to developing TCM\u2010related cardiac complications than were nonobese TCM patients, without any impact on all\u2010cause in\u2010hospital mortality, LOS, and hospital charges.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.22999","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T14:57:31Z","timestamp":1529420251000},"page":"1028-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Does obesity affect the outcomes in takotsubo cardiomyopathy? 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