{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:42:27Z","timestamp":1785177747670,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation (AF) is associated with diminished cardiac function, and exercise tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We sought to investigate the role of cardiac rehabilitation program (CR) in patients with AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 2165 consecutive patients that participated in our CR program between the years 2009 to 2015. All were evaluated by a standard exercise stress test (EST) at baseline, and upon completion of at least 3 months of training. Participants were dichotomized according to baseline fitness and the degree of functional improvement. The combined primary end point was cardiac related hospitalization or all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 292 patients had history of AF, with a mean age of 68 \u00b1 9 years old, 76% of which were males. The median predicted baseline fitness of AF patients was significantly lower compared to non\u2010AF patients (103% vs 122%, <jats:italic>P<\/jats:italic> &lt; 0.001, respectively). Prominent improvement was achieved in the majority of the patients in both groups (64% among AF patients and 63% among those without AF). Median improvement in fitness between stress tests was significantly higher in patients with AF (124% vs 110%, <jats:italic>P<\/jats:italic> &lt; 0.001, respectively). Among AF patients, high baseline fitness was associated with a lower event rates (HR 0.40; 95%CI 0.23\u20100.70; <jats:italic>P<\/jats:italic> = 0.001). Moreover, prominent improvement during CR showed a protective effect (HR 0.83; 95% CI 0.69\u20100.99; <jats:italic>P<\/jats:italic> = 0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with AF participating in CR program, low fitness levels at baseline EST are associated with increased risk of total mortality or cardiovascular hospitalization during long\u2010term follow\u2010up. Improvement on follow\u2010up EST diminishes the risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23001","type":"journal-article","created":{"date-parts":[[2018,6,23]],"date-time":"2018-06-23T08:59:41Z","timestamp":1529744381000},"page":"1170-1176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The role and outcome of cardiac rehabilitation program in patients with atrial fibrillation"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-5025","authenticated-orcid":false,"given":"Arwa","family":"Younis","sequence":"first","affiliation":[{"name":"The Leviev Heart Center, Sheba Medical Center  Ramat Gan Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Shaviv","sequence":"additional","affiliation":[{"name":"The Leviev Heart Center, Sheba Medical Center  Ramat Gan Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Nof","sequence":"additional","affiliation":[{"name":"The Leviev Heart Center, Sheba Medical Center  Ramat Gan Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Israel","sequence":"additional","affiliation":[{"name":"The Leviev Heart Center, Sheba Medical Center  Ramat Gan Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Berkovitch","sequence":"additional","affiliation":[{"name":"The Leviev Heart Center, Sheba Medical Center  Ramat Gan Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv 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Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Beinart","sequence":"additional","affiliation":[{"name":"The Leviev Heart Center, Sheba Medical Center  Ramat Gan Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center  Limburg the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_2_6_3_1","first-page":"CD001800","article-title":"Exercise\u2010based cardiac rehabilitation for coronary heart disease","volume":"1","author":"Anderson L","year":"2016","journal-title":"Cochrane Database Syst 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