{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:46:49Z","timestamp":1768402009946,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Familial hypercholesterolemia (FH) is an inherited disorder characterized by elevated plasma levels of low\u2010density lipoprotein cholesterol (LDL\u2010C) associated with premature cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the data from the START (STable Coronary Artery Diseases RegisTry) study, a nationwide, prospective survey on patients with stable coronary artery disease (CAD), we described prevalence and lipid lowering strategies commonly employed in these patients. The study population was divided into \u201cdefinite\/probable FH,\u201d defined as a Dutch Lipid Clinic Network (DLCN) score \u22656, \u201cpossible FH\u201d with DLCN 3\u20105, and \u201cunlikely FH\u201d in presence of a DLCN &lt;3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 4030 patients with the DLCN score available, 132 (3.3%) were classified as FH (2.3% with definite\/probable and 1.0% with possible FH) and 3898 (96.7%) had unlikely FH. Patients with both definite\/probable and possible FH were younger compared to patients not presenting FH. Mean on\u2010treatment LDL\u2010C levels were 107.8 \u00b1 41.5, 84.4 \u00b1 40.9, and 85.8 \u00b1 32.3 (<jats:italic>P<\/jats:italic> &lt; 0.0001) and a target of \u226470 mg\/dL was reached in 10.9%, 30.0%, and 22.0% (<jats:italic>P<\/jats:italic> &lt; 0.0001) of patents with definite\/probable, possible FH, and unlikely FH, respectively. Statin therapy was prescribed in 85 (92.4%) patients with definite\/probable FH, in 38 (95.0%) with possible FH, and in 3621 (92.9%) with unlikely FH (<jats:italic>P<\/jats:italic> = 0.86). The association of statin and ezetimibe, in absence of other lipid\u2010lowering therapy, was more frequently used in patients with definite\/probable FH compared to patients without FH (31.5% vs 17.5% vs 9.5%; <jats:italic>P<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large cohort of consecutive patients with stable CAD, FH was highly prevalent and generally undertreated with lipid lowering therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23031","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T05:34:06Z","timestamp":1532410446000},"page":"1075-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence and pharmacologic management of familial hypercholesterolemia in an unselected contemporary cohort of patients with stable coronary artery disease"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-1272","authenticated-orcid":false,"given":"Leonardo","family":"De Luca","sequence":"first","affiliation":[{"name":"Division of Cardiology S. Giovanni Evangelista Hospital  Tivoli Italy"},{"name":"ANMCO Research Center  Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Arca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties Sapienza University of Rome  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier L.","family":"Temporelli","sequence":"additional","affiliation":[{"name":"Division of Cardiology Istituti Clinici Scientifici Maugeri, IRCCS  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furio","family":"Colivicchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology S. Filippo Neri Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Gonzini","sequence":"additional","affiliation":[{"name":"ANMCO Research Center  Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donata","family":"Lucci","sequence":"additional","affiliation":[{"name":"ANMCO Research Center  Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biagio","family":"Bosco","sequence":"additional","affiliation":[{"name":"Division of Cardiology S. Giuseppe e Melorio Hospital  S. Maria Capua Vetere Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariella","family":"Callerame","sequence":"additional","affiliation":[{"name":"Division of Cardiology V. Fazzi Hospital  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio V.","family":"Lettica","sequence":"additional","affiliation":[{"name":"Division of Cardiology R. Guzzardi Hospital  Vittoria, Ragusa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Di Lenarda","sequence":"additional","affiliation":[{"name":"Cardiology Azienda Sanitaria Universitaria Integrata di Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele M.","family":"Gulizia","sequence":"additional","affiliation":[{"name":"Division of Cardiology Garibaldi\u2010Nesima Hospital  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the START Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000297"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018791"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.04.809"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2015.07.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv289"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.08.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.6.2025"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487317740663"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht273"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw272"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2011.03.452"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr158"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2003.11.010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.12.020"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.02.016"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00330-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7254.148"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.022764"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn422"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016080"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.09.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501031"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615664"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701488"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx549"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2016.08.011"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.69"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.08.009"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.23031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:20:00Z","timestamp":1695018000000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/clc.23031"],"URL":"https:\/\/doi.org\/10.1002\/clc.23031","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"2018-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}