{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:24:06Z","timestamp":1791901446970,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Most antiarrhythmic interventional therapies for atrial fibrillation (AF) have been provided with special focus on the treatment of left\u2010sided valvular disease and enlarged left atrium but few studies have assessed AF associated with congenital heart disease and dilated right atrium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>We hypothesized that right atrial (RA) function assessed by two\u2010dimensional (2DSTE) and three\u2010dimensional (3DSTE) speckle\u2010tracking echocardiography in patients with atrial septal defect (ASD) before and after percutaneous trancatheter closure could predict paroxysmal atrial fibrillation (PAF) development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010three patients with hemodynamically significant secundum ASD were prospectively studied and followed up for 6 months after occluder insertion and compared with a normal age\u2010matched group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200973). A subgroup of 17 patients who developed PAF after device implantation was also studied. RA peak global longitudinal strain (PS) was determined using 2DSTE. Standard deviations (SDs) of times to peak strain (TPS) were calculated as indices of dyssynchrony. RA volumes, emptying fraction (EF), and expansion index (EI) were determined using 3DSTE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RA\u2010PS, EF, and EI (pre\u2010closure values) were reduced in patients with atrial devices compared with controls, and further reductions were observed in patients with PAF. Pre\u2010closure 3D\u2010RA\u2010EI (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009) and RA\u2010TPS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.023) were independent predictors of PAF by multivariate analysis after adjustment for age and left atrial dysfunction. The areas under the ROC\u2010curve (AUC) for 3D\u2010RA\u2010EI, RA\u2010PS, RA\u2010TPS (pre\u2010closure values) showed high discriminative values(from 0.76 to 0.85) in predicting PAF. By combining 3D\u2010RA\u2010EI and RA\u2010TPS, the AUC increased to 0.90.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Two\u2010dimensional and three\u2010dimensional speckle tracking echocardiography was clinically helpful in ASD patients in revealing right atrial dilatation and dysfunction pre\u2010existent to device closure and associated with PAF development. RA parameters had a higher association with PAF compared to both the size of the implanted device and left atrial indices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.23051","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T04:04:41Z","timestamp":1534478681000},"page":"1341-1347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Right atrial function by speckle tracking echocardiography in atrial septal defect: Prediction of atrial fibrillation"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-2204","authenticated-orcid":false,"given":"Antonio","family":"Vitarelli","sequence":"first","affiliation":[{"name":"Cardiac Department Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Mangieri","sequence":"additional","affiliation":[{"name":"Cardiac Department 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