{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:38:11Z","timestamp":1761863891567,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T00:00:00Z","timestamp":1542326400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Compromised renal function is a major risk factor that is strongly associated with poor outcome in patients with mitral regurgitation (MR) and heart failure. Cystatin C, a cysteine protease inhibitor, has been used as a specific and sensitive biomarker of renal function. Neutrophil gelatinase\u2010associated lipocalin (NGAL) is another sensitive biomarker that specifically indicates functional and structural kidney damage. The aim of the present study was to determine the predictive value of serum cystatin C and urinary NGAL as indicators of mortality in patients undergoing percutaneous mitral valve repair (PMVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 120 consecutive patients (age: 77.3\u2009years [\u00b111.2]) undergoing PMVR using the MitraClip system were included in this study. Venous blood and urinary samples were collected for biomarker analysis prior to PMVR. Physiological parameters, medication use, safety events, and all\u2010cause mortality were assessed 12\u2009months after the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve months after PMVR, there was a significant reduction in the severity of MR (<jats:italic>P<\/jats:italic> &lt; 0.001), and an improvement in the New York Heart Association class (<jats:italic>P<\/jats:italic> &lt; 0.01) was documented. Baseline levels of serum cystatin C (nonsurvivors: 2.4 mg\/L [interquartile, IQR: 1.7;3.1] vs survivors: 1.7 mg\/L [IQR: 1,3;2.1], <jats:italic>P<\/jats:italic> &lt; 0.001) and urinary NGAL (nonsurvivors: 242.0 ng\/mL [IQR: 154.5;281.5] vs survivors: 132.0 ng\/mL [IQR:107.0;177.3], <jats:italic>P<\/jats:italic> &lt; 0.001) were significantly higher in patients who died during the 12\u2010month follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cystatin C and urinary NGAL were found to be predictors of long\u2010term mortality in high\u2010risk patients undergoing PMVR. Thus, cystatin C and NGAL assessment may be helpful in risk stratification in patients undergoing PMVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23089","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T19:01:48Z","timestamp":1538766108000},"page":"1474-1479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of cystatin C and neutrophil gelatinase\u2010associated lipocalin as predictors of mortality in patients undergoing percutaneous mitral valve repair (MitraClip)"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4526-6956","authenticated-orcid":false,"given":"Oliver","family":"D\u00f6rr","sequence":"first","affiliation":[{"name":"Department of Cardiology University of Giessen  Frankfurt Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site RheinMain  Frankfurt 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