{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:00:36Z","timestamp":1790690436187,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011074","name":"Universit\u00e9 de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several preliminary analyses suggested an association between neprilysin (NEP) levels and myocardial infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>\n                      The objective was to assess whether NEP plasma levels following reperfusion might be a surrogate for infarct size (IS) or predict adverse outcomes in acute ST\u2010segment elevation myocardial infarction\n                      <jats:bold>(<\/jats:bold>\n                      STEMI) patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured NEP levels in a prospective cohort of 203 patients with STEMI referred for primary percutaneous coronary intervention. Circulating soluble NEP was measured by enzyme\u2010linked immunosorbent assay at admission (t0) and 4 hours later (t4) following reperfusion and on 7 times points (t0, t4, t12, t24, t48, day 7 and day 30) in a subset of 21 patients. IS and left ventricular ejection fraction (LVEF) were measured at 1 month by cardiac magnetic resonance. Adverse cardiovascular outcomes were collected at 12\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median t0 and t4 NEP levels in 203 patients were respectively 88.3 pg\/mL (interquartile range [IQR] [14; 375.4]) and 101.5 pg\/mL (IQR [18.5; 423.8]). These levels remained unchanged over 1 month (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.70). NEP levels did not correlate significantly with IS (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.51) or LVEF (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.34). There was no correlation between NEP and troponin, creatine kinase and interleukin\u20106 levels at h0 and h4. NEP levels above the median were not associated with adverse outcomes at follow\u2010up (hazard ratio = 1.28, 95% confidence interval [0.69; 2.37];\n                      <jats:italic>P<\/jats:italic>\n                      = 0.42).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NEP serum levels were widely distributed and did not change significantly in the first hours and 1\u2010month period following reperfusion in STEMI patients. There was no significant relationship with markers of infarct size and inflammation, and 1\u2010year adverse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.23090","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T15:09:44Z","timestamp":1538752184000},"page":"32-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Neprilysin levels at the acute phase of ST\u2010elevation myocardial infarction"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7836-2074","authenticated-orcid":false,"given":"Hugo","family":"Bernelin","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Soins Intensifs Cardiologiques H\u00f4pital Louis Pradel, Hospices Civils de Lyon Lyon 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Universit\u00e9 Jean\u2010Monnet Saint\u2010\u00c9tienne France"},{"name":"Univ Lyon, UJM\u2010Saint\u2010Etienne INSA, CNRS UMR 5520, INSERM U1206, CREATIS Saint\u2010\u00c9tienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Rioufol","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Cardiologie Interventionnelle H\u00f4pital Louis Pradel, Hospices Civils de Lyon Lyon France"},{"name":"INSERM U1060, CarMeN Laboratory Universit\u00e9 de Lyon, Groupement Hospitalier Est Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bonnefoy\u2010Cudraz","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Soins Intensifs Cardiologiques H\u00f4pital Louis Pradel, Hospices Civils de Lyon Lyon France"},{"name":"INSERM U1060, CarMeN Laboratory Universit\u00e9 de Lyon, Groupement Hospitalier Est Bron 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