{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:30:58Z","timestamp":1779877858971,"version":"3.53.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["R01HL08929"],"award-info":[{"award-number":["R01HL08929"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL089292"],"award-info":[{"award-number":["R01HL089292"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004897","name":"Pennsylvania Department of Health","doi-asserted-by":"publisher","award":["ME\u201002\u2010384"],"award-info":[{"award-number":["ME\u201002\u2010384"]}],"id":[{"id":"10.13039\/100004897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ideal cardiovascular health (CVH) was proposed by the American Heart Association to promote population health. We aimed to characterize the association between ideal CVH and markers of subclinical cardiovascular disease (CVD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that ideal CVH is associated with several markers of subclinical CVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study. We assigned 1 for each of the ideal CVH factors met. Endothelial function, expressed as Framingham reactive hyperemia index (fRHI), was measured using the EndoPAT device. Coronary artery calcium (CAC) and carotid intima\u2010media thickness (CIMT) were quantified using electron beam computed tomography and carotid ultrasonography, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1933 participants (mean [SD] age: 59 [7.5] years, 34% male, 44% black) were included. The mean number of ideal CVH factors met was 2.3 \u00b1 1.3, with blacks having significantly lower score compared to whites (2.0 \u00b1 1.2 vs 2.5 \u00b1 1.4, respectively; <jats:italic>P<\/jats:italic> &lt; 0.001). Seven hundred and eighty\u2010nine participants (41%) achieved \u22653 ideal CVH factors. Participants with \u22653 ideal CVH factors (compared to those with &lt;3 factors) had an average of 107 (95% confidence interval [CI]: 50\u2010165) Agatston units lower CAC, 0.04 (0.01\u20100.06) mm lower CIMT, and 0.07 (0.02\u20100.12) units higher fRHI, after adjusting for age, sex, race, income, education, and marital status. Participants with \u22653 ideal CVH factors had 50% lower odds (95% CI: 28%\u201066%) of having CAC &gt;100 Agatston units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a community\u2010based study with low prevalence of ideal CVH, even achieving three or more ideal CVH factors were associated with lower burden of subclinical CVD, indicating the utility of this construct for disease prevention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23096","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T06:48:27Z","timestamp":1539586107000},"page":"1593-1599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Association between ideal cardiovascular health and markers of subclinical cardiovascular disease"],"prefix":"10.1002","volume":"41","author":[{"given":"Daniel","family":"Shpilsky","sequence":"first","affiliation":[{"name":"Department of Medicine 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