{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:39:48Z","timestamp":1791549588972,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>This systematic review and meta\u2010analysis sought to summarize the available evidence on the use of transcatheter aortic valve replacement (TAVR) in patients with Native Aortic Valve Regurgitation (NAVR) and compare outcomes between first and second generation valves. Owing to the improvements in transcatheter heart valve design and procedural success, TAVR has become increasingly performed in broader aortic valve pathologies. We searched Medline, Embase, Cochrane, and Scopus databases from 2007 to 2018 and performed a systematic review on reports with at least 10 patients with aortic valve regurgitation undergoing TAVR procedure. The main outcome of interest was all\u2010cause mortality at 30 days. A total of 638 patients across 12 studies were included. Mean age ranged from 68 to 84. Society of Thoracic Surgeons score ranged from 5.4% to 13.1% and Logistic EuroSCORE ranged from 18.2% to 33%. The incidence rate of all\u2010cause mortality at 30 days was found to be 11% (95% CI 7%\u201016%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 20.86%). All\u2010cause mortality at 30 days for first generation valves had an incidence rate of 15% (95% CI 10%\u201020%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 10%) compared to 7% (95% CI 3%\u201013%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 37%) in second generation valves with subgroup interaction analysis <jats:italic>P<\/jats:italic> = 0.059. Device success incidence rate in second generation valves was 92% (95% CI 83%\u201099%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 67%) vs 68% (95% CI 59%\u201077%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 53%) in first generation valves with <jats:italic>P<\/jats:italic> = 0.001. TAVR appears to be a feasible treatment choice for NAVR patients at high risk for surgical valve replacement. Second generation valves show promising results in terms of short\u2010term outcomes.<\/jats:p>","DOI":"10.1002\/clc.23103","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T07:50:50Z","timestamp":1540281050000},"page":"159-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Transcatheter aortic valve replacement in patients with pure native aortic valve regurgitation: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6984-4717","authenticated-orcid":false,"given":"Abdullah","family":"Haddad","sequence":"first","affiliation":[{"name":"Division of Cardiology Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania. 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