{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:11:19Z","timestamp":1790503879302,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T00:00:00Z","timestamp":1543536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence of left ventricular thrombus (LVT) is 4% to 15% in patients with anterior acute ST\u2010segment elevation myocardial infarction (ant\u2010AMI) in the era of primary percutaneous coronary intervention (PPCI). And patients with LVT have higher in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>There is a relationship between LVT formation and 1\u2010year major adverse cardio\u2010cerebrovascular events (MACCE) in patients with ant\u2010AMI treated by PPCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study population included 1488 consecutive patients with ant\u2010AMI. The primary endpoint was the incidence of MACCE within 1 year after AMI. The secondary endpoint was the thrombosis disappearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 106 (7.1%) patients were diagnosed with LVT and 1382 (92.9%) patients without LVT. Patients with LVT had a higher incidence of MACCE than in patients without LVT (21.7%vs10.3%; <jats:italic>P<\/jats:italic> &lt; 0.001). Univariate analysis showed LVT was associated with an increase in MACCE risk (odds ratio [OR] = 2.40; 95% confidence interval [CI] [1.37\u20104.21]; <jats:italic>P<\/jats:italic> &lt; 0.001). When examining MACCE components individually, LVT was only associated with the incidence of congestive heart failure (OR = 2.41; 95% CI [1.29\u20104.58]; <jats:italic>P<\/jats:italic> = 0.001). After adjustment for principal confounders, LVT remained an independent risk factor for MACCE (HR = 2.28; 95% CI [1.12\u20106.38]; <jats:italic>P<\/jats:italic> = 0.020). Other independent predictors include 24\u2010hour LVEF, creatine kinase peak value, and age. Further analysis found patients with LVT in international normalized ratio (INR) \u2265 2 group had lower MACCE risk and higher thrombus disappearance than in INR &lt; 2 group (13.5%vs29.6%; <jats:italic>P<\/jats:italic> = 0.044; 90.4%vs74.1%; <jats:italic>P<\/jats:italic> = 0.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For patients with ant\u2010AMI treated by PPCI, LVT is an independent predictor of 1\u2010year MACCE events. Treatment with vitamin K antagonist in the therapeutic range (INR \u2265 2) has the potential to reduce MACCE risk and promote disappearance of thrombus.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23106","type":"journal-article","created":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T07:43:27Z","timestamp":1540626207000},"page":"69-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Relationship of left ventricular thrombus formation and adverse outcomes in acute anterior myocardial infarction in patients treated with primary percutaneous coronary intervention"],"prefix":"10.1002","volume":"42","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Emergency, Beijing Anzhen Hospital Capital Medical University  Beijing 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