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Furthermore, administration of cangrelor prior to reperfusion has been shown in pre\u2010clinical studies to reduce myocardial infarct (MI) size. Therefore, we hypothesize that cangrelor administered prior to reperfusion in STEMI patients will reduce the incidence of microvascular obstruction (MVO) and limit MI size in STEMI patients treated with PPCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The platelet inhibition to target reperfusion injury (PITRI) trial, is a phase 2A, multi\u2010center, double\u2010blinded, randomized controlled trial, in which 210 STEMI patients will be randomized to receive either an intravenous (IV) bolus of cangrelor (30 \u03bcg\/kg) followed by a 120\u2010minute infusion (4 \u03bcg\/kg\/min) or matching saline placebo, initiated prior to reperfusion (NCT03102723).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study started in October 2017 and the anticipated end date would be July 2020. The primary end\u2010point will be MI size quantified by cardiovascular magnetic resonance (CMR) on day 3 post\u2010PPCI. Secondary endpoints will include markers of reperfusion, incidence of MVO, MI size, and adverse left ventricular remodeling at 6 months, and major adverse cardiac and cerebrovascular events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p>The aim of the PITRI trial is to assess whether cangrelor administered prior to reperfusion would reduce acute MI size and MVO, as assessed by CMR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23110","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T05:40:37Z","timestamp":1542087637000},"page":"5-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Platelet inhibition to target reperfusion injury trial: Rationale and study design"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-1783","authenticated-orcid":false,"given":"Heerajnarain","family":"Bulluck","sequence":"first","affiliation":[{"name":"The Hatter Cardiovascular Institute, Institute of Cardiovascular Science University College London  London UK"},{"name":"Department of Cardiology Norfolk and Norwich University Hospital  Norwich UK"},{"name":"Department of Cardiology National Heart Centre Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervyn H. 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