{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:35:46Z","timestamp":1768012546418,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The renin\u2010angiotensin system plays an important role in promoting atherosclerotic plaque inflammation, which may be inhibited by angiotension\u2010II receptor blockers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We investigated the effects of fimasartan and amlodipine therapy on carotid atherosclerotic plaque inflammation using <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (<jats:sup>18<\/jats:sup>FDG) positron emission tomography (PET) imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty patients with acute coronary syndrome (ACS) and at least one lesion with <jats:sup>18<\/jats:sup>FDG uptake in the carotid artery (target\u2010to\u2010background ratio [TBR] \u2265 1.6) were randomly assigned to receive either fimasartan (60 mg once a day) or amlodipine (5 mg once a day). <jats:sup>18<\/jats:sup>FDG PET examinations were performed in all patients at baseline and 6 months. The primary endpoint was the percent change in the index vessel TBR for the most diseased segment (MDS TBR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two groups had similar baseline characteristics. At the 6\u2010month follow\u2010up, index vessel and aorta MDS TBR significantly decreased in both groups. However, the percent change in index vessel MDS TBR was similar between the two groups (\u22129.33 \u00b1 14.2% vs \u22127.73 \u00b1 19.1%, respectively, <jats:italic>P<\/jats:italic> = 0.9). No significant difference was found for the percent change in the whole vessel TBR for the index vessel between the two groups, with similar findings for changes in MDS TBR or whole vessel TBR for the aorta. Total cholesterol, low\u2010density lipoprotein cholesterol levels, and blood pressure improved to a similar degree in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fimasartan and amlodipine reduce carotid atherosclerotic plaque inflammation similarly in patients with ACS, offering the same level of effectiveness.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23133","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T04:14:10Z","timestamp":1544415250000},"page":"241-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of fimasartan and amlodipine therapy on carotid atherosclerotic plaque inflammation"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-3215","authenticated-orcid":false,"given":"Minyoung","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol Whan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6643-0239","authenticated-orcid":false,"given":"Duk\u2010Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Jin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Whan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Hak","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Hyuk","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ulsan College of Medicine  Seoul South 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