{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:21:12Z","timestamp":1791868872876,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL102429"],"award-info":[{"award-number":["HL102429"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL069912"],"award-info":[{"award-number":["HL069912"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There is limited data on electrocardiographic (ECG) abnormalities and their prognostic significance in women with peripartum cardiomyopathy (PPCM). We sought to characterize ECG findings in PPCM and explore the association of ECG findings with myocardial recovery and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that ECG indicators of myocardial remodeling would portend worse systolic function and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Standard 12\u2010lead ECGs were obtained at enrollment in the Investigations of Pregnancy\u2010Associated Cardiomyopathy study and analyzed for 88 women. Left ventricular ejection fraction (LVEF) was measured by echocardiography at baseline, 6 months, and 12\u2009months. Women were followed for clinical events (death, mechanical circulatory support, and\/or cardiac transplantation) until 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Half of women had an \u201cabnormal\u201d ECG, defined as atrial abnormality, ventricular hypertrophy, ST\u2010segment deviation, and\/or bundle branch block. Women with left atrial abnormality (LAA) had lower LVEF at 6 months (44% vs 52%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and 12\u2009months (46% vs 54%, <jats:italic>P<\/jats:italic>\u2009=\u20090.03). LAA also predicted decreased event\u2010free survival at 1 year (76% vs 97%, <jats:italic>P<\/jats:italic>\u2009=\u20090.008). Neither left ventricular hypertrophy by ECG nor T\u2010wave abnormalities predicted outcomes. A normal ECG was associated with recovery in LVEF to \u226550% (84% vs 49%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and event\u2010free survival at 1 year (100% vs 85%, <jats:italic>P<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ECG abnormalities are common in women with PPCM, but a normal ECG does not rule out the presence of PPCM. LAA predicted lower likelihood of myocardial recovery and event\u2010free survival, and a normal ECG predicted favorable event\u2010free survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23171","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T08:20:25Z","timestamp":1551946825000},"page":"524-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Electrocardiographic findings in peripartum cardiomyopathy"],"prefix":"10.1002","volume":"42","author":[{"given":"Michael C.","family":"Honigberg","sequence":"first","affiliation":[{"name":"Cardiology Division, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Elkayam","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Keck School of Medicine University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplant Cardiology, Newark Beth Israel Medical Center  Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalgi","family":"Modi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Louisiana State University Health Sciences Center  Shreveport Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan E.","family":"Briller","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Illinois at Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Drazner","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen L.","family":"Wells","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplant Cardiology, Newark Beth Israel Medical Center  Newark New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis M.","family":"McNamara","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, University of Pittsburgh Medical Center University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1012-7710","authenticated-orcid":false,"given":"Michael M.","family":"Givertz","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women's Hospital Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the IPAC Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22932"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k5287"},{"key":"e_1_2_7_4_1","first-page":"228","article-title":"Epidemiologic profile of peripartum cardiomyopathy in a tertiary care hospital","volume":"17","author":"Isezuo SA","year":"2007","journal-title":"Ethn. 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