{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:56:07Z","timestamp":1790175367919,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We sought to investigate left atrial (LA) volume, function, and strain in elite athletes by a meta\u2010analysis including echocardiographic studies that provided volumetric and strain analysis of LA phasic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The OVID\u2010MEDLINE, PubMed, and Cochrane CENTRAL databases were searched for English\u2010language articles without time restriction up to February 2018 through focused and high sensitive search strategies<jats:bold>.<\/jats:bold> Studies were identified by crossing the following search terms: \u201cathletes,\u201d \u201cleft atrial size,\u201d \u201cleft atrial volume,\u201d \u201catrial function,\u201d \u201catrial strain,\u201d \u201catrial strain rate,\u201d \u201cechocardiography,\u201d \u201c2D speckle echocardiography.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Meta\u2010analysis included 403 athletes and 314 active but not trained healthy controls from 9 studies. Pooled data showed that average LA volume index was higher in athletes than in healthy controls (28.0 \u00b1 1.0 vs 20.7 \u00b1 0.8 mL\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic> &lt; 0.001). Global LA longitudinal strain, showing LA reservoir function, was lower in the athletes than in healthy controls with borderline significance (37.0 \u00b1 1.2 vs 38.3 \u00b1 1.5%, <jats:italic>P<\/jats:italic> = 0.044). Late diastolic LA strain rate, resembling LA contractile function, was also lower in elite athletes than in control group (\u22121.56\u2009\u00b1 0.08 vs \u22121.74\u2009\u00b1 0.09\u2009seconds \u22121, <jats:italic>P<\/jats:italic> = 0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis shows that LA volume is higher, while LA reservoir and contractile functions are impaired in elite athletes during active training compared to untrained controls. Whether these changes persist during deconditioning periods remains to be determined. These alterations may be related to the higher risk of arrhythmias, in particular atrial fibrillation, reported among middle\/old aged athletes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23180","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T03:15:05Z","timestamp":1553483705000},"page":"579-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Left atrial function in elite athletes: A meta\u2010analysis of two\u2010dimensional speckle tracking echocardiographic studies"],"prefix":"10.1002","volume":"42","author":[{"given":"Cesare","family":"Cuspidi","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca  Milan Italy"},{"name":"Clinical Research Unit Istituto Auxologico Italiano, IRCCS  Milan 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