{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:31:47Z","timestamp":1790400707195,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Wake\u2010Up T2MI Registry is a retrospective cohort study investigating patients with type 2 myocardial infarction (T2MI), acute myocardial injury, and chronic myocardial injury. We aim to explore risk stratification strategies and investigate clinical characteristics, management, and short\u2010 and long\u2010term outcomes in this high\u2010risk, understudied population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 1 January 2009 to 31 December 2010, 2846 patients were identified with T2MI or myocardial injury defined as elevated cardiac troponin I with at least one value above the 99th percentile upper reference limit and coefficient of variation of 10% (&gt;40\u2009ng\/L) and meeting our inclusion criteria. Data of at least two serial troponin values will be collected from the electronic health records to differentiate between acute and chronic myocardial injury. The Fourth Universal Definition will be used to classify patients as having (a) T2MI, (b) acute myocardial injury, or (c) chronic myocardial injury during the index hospitalization. Long\u2010term mortality data will be collected through data linkage with the National Death Index and North Carolina State Vital Statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We have collected data for a total of 2205 patients as of November 2018. The mean age of the population was 65.6\u2009\u00b1\u200916.9 years, 48% were men, and 64% were white. Common comorbidities included hypertension (71%), hyperlipidemia (35%), and diabetes mellitus (30%). At presentation, 40% were on aspirin, 38% on \u03b2\u2010blockers, and 30% on statins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Improved characterization and profiling of this cohort may further efforts to identify evidence\u2010based strategies to improve cardiovascular outcomes among patients with T2MI and myocardial injury.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23182","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T03:35:08Z","timestamp":1554262508000},"page":"592-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Wake Forest University long\u2010term follow\u2010up of type 2 myocardial infarction: The Wake\u2010Up T2MI Registry"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9965-9638","authenticated-orcid":false,"given":"Hanumantha R.","family":"Jogu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Wake Forest School of Medicine  Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6387-3015","authenticated-orcid":false,"given":"Sameer","family":"Arora","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of North Carolina  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthiah","family":"Vaduganathan","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Heart &amp; 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