{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:44:31Z","timestamp":1747147471384,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Family history of heart disease (FH\u2010HD) is associated with an increase drisk of subsequent HD. High sensitive cardiac troponin T (hs\u2010cTnT) is arecognized biomarker of myocyte injury even in HD free patients. We examined the association between FH\u2010HD and hs\u2010cTnT in apparently healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>FH\u2010HD is associated with elevated hs\u2010cTnT in apparently healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross sectional study we analyzed data of apparently healthy individuals (n=3,821) recruited for the Tel\u2010Aviv Medical Center Inflammation Survey (TAMCIS). Blood samples were obtained for hs\u2010cTnT and high sensitive CRP (hs\u2010CRP) among other tests. FH\u2010HD was defined as first degree family member with HD diagnosis and classified as premature if the diagnosis was done before the age of 55 for men or 65 for women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Elevated hs\u2010cTnT (&gt;14 ng\/L) was more common in FH\u2010HD of any age, and in premature FH\u2010HD (FH\u2010P\u2010HD) participants than in participants without FH\u2010HD (4.4% vs 2.0%, p&lt;0.001 and 4.3% vs 2.0%, p=0.001, respectively). Adjustmentfor potential risk factors with association to elevated hs\u2010cTnT (age, sex, BMI, hypertension, diabetes, hs\u2010CRP, smoking and physical activity), showed that FH\u2010HD and FH\u2010P\u2010HD remained significantly associated with elevated hs\u2010cTnT (OR=1.62, p=0.025 and OR=1.70, p=0.039, respectively). Furthermore, we found that a significant interaction between FH\u2010HD or FH\u2010P\u2010HD and high levels ofhs\u2010CRP (&gt;3 mg\/L) increased the risk for elevated hs\u2010cTnT (OR=3.07, p=0.036 for FH\u2010HD and OR=3.25, p=0.053 for FH\u2010P\u2010HD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FH\u2010HD and its interaction with elevated hs\u2010CRP levels were significantly associated with elevated hs\u2010cTnT in apparently healthy individuals suggesting that an inflammatory process may be involved in this association.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23214","type":"journal-article","created":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T06:32:54Z","timestamp":1559975574000},"page":"760-767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Familial history of heart disease and increased risk for elevated troponin in apparently healthy individuals"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-6765","authenticated-orcid":false,"given":"Noa","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine \u201cC\u201d, \u201cD\u201d and \u201cE\u201d, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0172-2852","authenticated-orcid":false,"given":"Rafael Y.","family":"Brzezinski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u201cC\u201d, \u201cD\u201d and \u201cE\u201d, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Ehrenwald","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u201cC\u201d, \u201cD\u201d and \u201cE\u201d, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itzhak","family":"Shapira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u201cC\u201d, \u201cD\u201d and \u201cE\u201d, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Zeltser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u201cC\u201d, \u201cD\u201d and \u201cE\u201d, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shlomo","family":"Berliner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u201cC\u201d, \u201cD\u201d and \u201cE\u201d, 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