{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:28:51Z","timestamp":1761989331987,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vasospastic angina (VSA) is characterized by coronary spasm, which can be aggravated by vasoactive substances such as serotonin. Hypothesis Sarpogrelate, a selective serotonin receptor antagonist, and high\u2010dose statin have some effects on the reduction of coronary spasm in patients with VSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 100 patients with angiographically confirmed VSA, and randomly assigned them into four groups: sarpogrelate with high\u2010dose statin (Group A, n = 25), sarpogrelate with low\u2010dose or no statin (Group B, n = 25), placebo with high\u2010dose statin (Group C, n = 25), and placebo with low\u2010dose or no statin (Group D, n = 25). The primary endpoint was the remission of coronary spasm on 1\u2010year follow\u2010up provocation test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common site of coronary spasm was left anterior descending artery (42%). Most patients (96%) took calcium channel blockers, and 46% were treated with vasodilators. Overall, 40% of patients reported no chest pain at 1 year, and 23% showed complete remission of coronary spasm on 1\u2010year follow\u2010up provocation test. No difference was observed in symptomatic and angiographically complete remission rate between the sarpogrelate and the placebo group. Although the apolipoprotein B level at the 1\u2010year follow\u2010up was significantly lower in the high\u2010dose statin group, symptomatic and angiographic outcomes were not different according to statin intensity. Distal thrombolysis in myocardial infarction (TIMI) flow on initial provocation test was independently associated with angiographically complete remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sarpogrelate or high\u2010dose statin did not significantly improve the angiographic remission rate in patients with VSA. Distal TIMI flow on initial provocation test could predict the complete remission of coronary spasm at follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23239","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T14:39:45Z","timestamp":1563979185000},"page":"899-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of sarpogrelate and high\u2010dose statin on the reduction of coronary spasm in vasospastic angina: A two by two factorial, pilot randomized study"],"prefix":"10.1002","volume":"42","author":[{"given":"So Ree","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki 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