{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:21:51Z","timestamp":1782948111233,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Premature ventricular complexes (PVCs) are the most common form of ventricular arrhythmia in the general population. While in most cases PVCs represent a primitive phenomenon with benign behavior, in a non\u2010negligible proportion of subjects frequent PVCs may be epiphenomenon of underlying occult heart diseases, requiring special medical attention since they have been resulted linked to increased total and cardiac mortality. Nevertheless, PVCs themselves, when incessantly frequent, may be responsible for left ventricular dysfunction in otherwise normal heart. Aim of this narrative review is to update current knowledge on the general approach to patients with frequent PVCs on the basis of available data, with a special focus on the value of imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Routine diagnostic work\u2010up not infrequently miss subtle concealed arrhythmic substrate, leading to erroneously refer to such arrhythmias as to \u201cidiopathic\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature search of PVCs articles was conducted in PubMed and Scopus electronic database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Conflicting data arise from literature about the true clinical significance of idiopathic PVCs. There is growing body of data providing evidence that more advanced non\u2010invasive imaging modalities, such as cardiac magnetic resonance, have an incremental diagnostic and prognostic value. On the other hand, in some cases the prognostic significance of isolated subtle myocardial structural abnormalities in patients with PVCs, still remains area of uncertainty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In selected subjects with PVCs and high\u2010risk features for concealed arrhythmic substrate, traditional assessment to rule out the presence of heart disease, including surface ECG and transthoracic echocardiography, should be implemented with more advanced cardiovascular imaging modalities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23271","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T06:04:40Z","timestamp":1569909880000},"page":"1162-1169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Detection of concealed structural heart disease by imaging in patients with apparently idiopathic premature ventricular complexes: A review of current literature"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9028-7169","authenticated-orcid":false,"given":"Biagio","family":"Sassone","sequence":"first","affiliation":[{"name":"Cardiology Division, SS.ma Annunziata Hospital, Department of Emergency Azienda Unit\u00e0 Sanitaria Locale di Ferrara  Ferrara Italy"},{"name":"Cardiology Division, Delta Hospital, Department of Emergency Azienda Unit\u00e0 Sanitaria Locale di Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Muser","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department, University Hospital Piazzale Santa Maria della Misericordia 15  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Casella","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Centro Cardiologico Monzino  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Luzi","sequence":"additional","affiliation":[{"name":"Cardiology Division Ospedale Provinciale AREA VASTA 3  Macerata MC Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santo","family":"Virz\u00ec","sequence":"additional","affiliation":[{"name":"Cardiology Division, SS.ma Annunziata Hospital, Department of Emergency Azienda Unit\u00e0 Sanitaria Locale di Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Balla","sequence":"additional","affiliation":[{"name":"Cardiology Department, S. 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