{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:12:56Z","timestamp":1791231176669,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T00:00:00Z","timestamp":1570060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Scrub typhus is a well\u2010known infectious disorder of the Asia\u2010Pacific region. However, adverse cardiac outcomes are an under\u2010recognized complication of scrub typhus infection, and new\u2010onset AF has been reported to be a prognostic factor in other, more common infectious diseases. The present study investigated whether new\u2010onset atrial fibrillation (AF) is significantly associated with 3\u2010month mortality and adverse cardiac complications in scrub typhus infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined data from the National Health Information Database (NHID) which covers nearly the entire population of South Korea, from 2006 to 2016. In total, 233\u2009473 patients diagnosed with scrub typhus infection were selected as study participants. New\u2010onset AF, acute heart failure (AHF), ischemic heart disease (IHD), and 3\u2010month mortality were analyzed using a generalized estimating equation model with a Poisson distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of these, 2402 patients (1%) were diagnosed with new\u2010onset AF (87.2% were over 60\u2009years of age, 43.3% were male). Those with new\u2010onset AF were more likely to have underlying cardiovascular disease compared to those without new\u2010onset AF. After being adjusted for demographic factors and comorbidities, those with new\u2010onset AF had a higher incidence risk of concurrent AHF (4.1\u2010fold) and IHD (1.9\u2010fold) compared with those without new\u2010onset AF. In particular, the 3\u2010month mortality was also significantly associated with new\u2010onset AF (1.3\u2010fold), concurrent AHF (2.4\u2010fold), and IHD (13.7\u2010fold).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>New\u2010onset AF was significantly associated with 3\u2010month mortality and concurrent AHF and IHD. Therefore, new\u2010onset AF could be a poor prognostic factor for 3\u2010month mortality and cardiac complications in scrub typhus infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23276","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T15:18:22Z","timestamp":1570115902000},"page":"1210-1221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["New\u2010onset atrial fibrillation predicting for complicating cardiac adverse outcome in scrub typhus infection"],"prefix":"10.1002","volume":"42","author":[{"given":"Suk\u2010Yong","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine Eulji University School of Medicine  Daejeon Republic of 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